ReviewInternational journal of radiation oncology, biology, physics2013
Does quality of radiation therapy predict outcomes of multicenter cooperative group trials? A literature review.
Review in International journal of radiation oncology, biology, physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiologist Involvement in Radiation Oncology Peer Review: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Personalising treatment plan quality review with knowledge-based planning in the TROG 15.03 trial for stereotactic ablative body radiotherapy in primary kidney cancer.Radiation oncology (London, England) · 2021Trial
- Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma : First experiences of the German radiotherapy quality control panel in the SIOP PNET5 MB trial.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Trial
- A dedicated cloud system for real-time upfront quality assurance in pediatric radiation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Trial
- Improving Quality and Consistency in NRG Oncology Radiation Therapy Oncology Group 0631 for Spine Radiosurgery via Knowledge-Based Planning.International journal of radiation oncology, biology, physics · 2018Trial
- Implementation of a rapid learning platform: Predicting 2-year survival in laryngeal carcinoma patients in a clinical setting.Oncotarget · 2016Trial
- Quantifying Unnecessary Normal Tissue Complication Risks due to Suboptimal Planning: A Secondary Study of RTOG 0126.International journal of radiation oncology, biology, physics · 2015Trial
- Quality assurance for the EORTC 22071-26071 study: dummy run prospective analysis.Radiation oncology (London, England) · 2014Trial
- Trial
- Disease-Site Specific Peer Review Implementation: From Chart Rounds to the Treatment Couch.Advances in radiation oncology · 2026Article
- Version upgrades in treatment planning Systems affect clinical application of a multi-Centre knowledge-based planning model.Technical innovations & patient support in radiation oncology · 2026Article
- Current practices in peer review in German radiation oncology: a nationwide survey.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Provider Practices and Perceived Barriers and Facilitators in Improving Quality Practices in Radiation Oncology Peer Review.Advances in radiation oncology · 2025Article
- Development and psychometric validation of a patient safety assessment tool in German Radiation Oncology: the PaSaGeRO Study protocol.BMJ open · 2024Article
- Multicenter Study of Pelvic Nodal Autosegmentation Algorithm of Siemens Healthineers: Comparison of Male Versus Female Pelvis.Advances in radiation oncology · 2024Article
- The Importance of Quality Assurance in Radiation Oncology Clinical Trials.Seminars in radiation oncology · 2023Review
- Automated contouring and statistical process control for plan quality in a breast clinical trial.Physics and imaging in radiation oncology · 2023Article
- Quality improvements in radiation oncology clinical trials.Frontiers in oncology · 2023Review
- Lung SBRT credentialing in the Canadian OCOG-LUSTRE randomized trial.Clinical and translational radiation oncology · 2022Article
- Demystifying radiation oncology clinical trial concerns for protocol scientific review and institutional review board committee members.Contemporary clinical trials communications · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Central review of radiation therapy (RT) delivery within multicenter clinical trials was initiated in the early 1970s in the United States. Early quality assurance publications often focused on metrics related to process, logistics, and timing. Our objective was to review the available evidence supporting correlation of RT quality with clinical outcomes within cooperative group trials. A MEDLINE search was performed to identify multicenter studies that described central subjective assessment of RT protocol compliance (quality). Data abstracted included method of central review, definition of deviations, and clinical outcomes. Seventeen multicenter studies (1980-2012) were identified, plus one Patterns of Care Study. Disease sites were hematologic, head and neck, lung, breast, and pancreas. Between 0 and 97% of treatment plans received an overall grade of acceptable. In 7 trials, failure rates were significantly higher after inadequate versus adequate RT. Five of 9 and 2 of 5 trials reported significantly worse overall and progression-free survival after poor-quality RT, respectively. One reported a significant correlation, and 2 reported nonsignificant trends toward increased toxicity with noncompliant RT. Although more data are required, protocol-compliant RT may decrease failure rates and increase overall survival and likely contributes to the ability of collected data to answer the central trial question.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.