ArticleParasites & vectors2013
Sterilising effects of pyriproxyfen on Anopheles arabiensis and its potential use in malaria control.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 88 citations in OpenAlex.
- Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial.Malaria journal · 2019Trial
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- Sublethal Pyriproxyfen Exposure AltersInsects · 2026Article
- Susceptibility of the invasive malaria vector Anopheles stephensi in Ethiopia to novel chemical insecticides and insect growth regulator.Scientific reports · 2025Article
- Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.Pest management science · 2025Article
- Insecticide susceptibility status of Anopheles stephensi against novel insecticides in Eastern Ethiopia.Research square · 2024Article
- The impact of non-lethal doses of pyriproxyfen on male and femaleFrontiers in insect science · 2024Article
- Pyriproxyfen, villain or good guy? A brief review.Archives of endocrinology and metabolism · 2024Review
- Community perception of the autodissemination of pyriproxyfen for controlling malaria vectors in south-eastern Tanzania.Malaria journal · 2023Article
- Sterilized Anopheles funestus can autodisseminate sufficient pyriproxyfen to the breeding habitat under semi-field settings.Malaria journal · 2023Article
- Ovary Dissection Is a Sensitive Measure of Sterility inInsects · 2023Article
- Indirect transfer of pyriproxyfen to European honeybees via an autodissemination approach.PLoS neglected tropical diseases · 2021Article
- Evaluation of a mosquito home system for controlling Aedes aegypti.Parasites & vectors · 2021Article
- Juvenile Hormone-Sensitive Ribosomal Activity Enhances Viral Replication in Aedes aegypti.mSystems · 2021Article
- Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions.Malaria journal · 2021Article
- Article
- Assessing the efficacy of two dual-active ingredients long-lasting insecticidal nets for the control of malaria transmitted by pyrethroid-resistant vectors in Benin: study protocol for a three-arm, single-blinded, parallel, cluster-randomized controlled trial.BMC infectious diseases · 2021Article
- Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes.PloS one · 2021Article
- Molecular action of pyriproxyfen: Role of the Methoprene-tolerant protein in the pyriproxyfen-induced sterilization of adult female mosquitoes.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsecticide resistance poses a major threat to current vector control campaigns. Insecticides with novel modes of action are therefore in high demand. Pyriproxyfen (PPF), a conventional mosquito pupacide, has a unique mode of action that also sterilises adult mosquitoes (unable to produce viable offspring) upon direct contact. However, the timing of PPF exposure in relation to when mosquitoes take a blood meal has an important impact on that sterilisation. This study investigated the relationship between different blood feeding and PPF exposure timings to determine the potential of PPF sterilisation in controlling Anopheles arabiensis.
methodsFour treatment regimens were investigated: blood fed three days before PPF exposure (A), blood fed one day before PPF exposure (B), blood fed one day after PPF exposure (C) and blood fed three days after PPF exposure (D) for their impact on egg laying (fecundity) and the production of viable offspring (fertility), while the impact of PPF exposure on mosquito survival was investigated in the absence of a blood meal. All regimens and the survival study exposed mosquitoes to PPF via the bottle assay at 3 mg AI/m(2) for 30 minutes.
resultsFemale mosquitoes that blood-fed one day prior to PPF exposure (regimen B), produced no viable offspring during that gonotrophic cycle (100% reduction in fertility). All other treatments had no significant effect. The observed reductions in fecundity and fertility were caused by the retention of eggs (97% of eggs retained, i.e. produced in the ovaries but not laid, in regimen B, p = 0.0004). Some of these retained eggs were deformed in shape. PPF exposure on mosquito survival in the absence of a blood meal was found to have no effect.
conclusionsThe results presented here suggest that sterilising adult malaria vectors using PPF could form part of a malaria control strategy, taking advantage of the lack of reported resistance to PPF in mosquitoes and its unique mode of action. We propose that targeting resting mosquitoes, which are highly susceptible to PPF at low doses, is the optimal direction for developing this control tool.
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