Evidence map›Paper›PMID 23683390›Full record

SynthesisBiological psychiatry2013

Meta-analysis of oxidative stress in schizophrenia.

Joshua Flatow, Peter Buckley, Brian J Miller

Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05142735 (Effects of N-acetylcysteine on Psychosis-like Symptoms and a Neurophysiological Biomarker of the Clinical High Risk for Schizophrenia), which is not on this map. Cited by 257 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
257citing papers in PubMed, 16 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05142735 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effects of N-acetylcysteine on Psychosis-like Symptoms and a Neurophysiological Biomarker of the Clinical High Risk for Schizophrenia

TypeinterventionalSponsorCentre for Addiction and Mental HealthRan2023 to 2026Enrolled90ConditionsProdromal SchizophreniaArmsN-Acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

257 citing papers in PubMed, 16 syntheses or guidelines pooled it, 476 citations in OpenAlex.

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  12. Natural Medicines for Psychotic Disorders: A Systematic Review.The Journal of nervous and mental disease · 2018
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197 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua FlatowMedical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.
Peter Buckley
Brian J Miller
Augusta University · US

Funding

A Potential State and Relapse Predictive Marker in SchizophreniaK23MH098014 · NIMH · AUGUSTA UNIVERSITY · PI MILLER, BRIAN JAMES · 2012 to 2016
$921k
NIMH NIH HHS 1K23MH098014-01NIMH NIH HHS K23 MH098014
6 · The paper itself

Abstract

backgroundSchizophrenia is associated with impaired antioxidant defense, including abnormal serum, plasma, and red blood cell (RBC) oxidative stress parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment after an acute exacerbation of psychosis.

methodsWe identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information, and the reference lists of identified studies.

resultsForty-four studies met the inclusion criteria. Total antioxidant status seemed to be a state marker, because levels were significantly decreased in cross-sectional studies of serum and plasma in first-episode psychosis (FEP) and significantly increased in longitudinal studies of antipsychotic treatment for acute exacerbations of psychosis (p < .01 for each). The RBC catalase and plasma nitrite seemed to be state-related markers, because levels in cross-sectional studies were significantly decreased in FEP (p < .01) and significantly increased in stable outpatients (p = .01). In contrast, RBC superoxide dismutase seemed to be a trait marker for schizophrenia, because levels in cross-sectional studies were significantly decreased in acutely relapsed inpatients, FEP, and stable outpatients (p < .01 for each).

conclusionsOxidative stress abnormalities in FEP suggest an effect that might be independent of antipsychotic medications. Although some parameters (total antioxidant status, RBC catalase, and plasma nitrite) might be state markers for acute exacerbations of psychosis, others (RBC superoxide dismutase) might be trait markers; however, more longitudinal studies are needed. Our findings suggest that oxidative stress might serve as a potential biomarker in the etiopathophysiology and clinical course of schizophrenia.

Indexed as

Oxidative StressHumansSchizophreniaAntioxidantsfirst-episode psychosismeta-analysisoxidative stressrelapseschizophrenia

Identifiers

PMID23683390
PMCPMC4018767
OpenAlexW2060038783

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.