Evidence map›Paper›PMID 23683127›Full record

ArticleNeuropathology : official journal of the Japanese Society of Neuropathology2014

Inflammatory infratentorial progressive multifocal leukoencephalopathy in a patient with rheumatoid arthritis.

Boleslaw Lach, Barbara Connolly, Christian Wüthrich, Igor J Koralnik

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropathology : official journal of the Japanese Society of Neuropathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Boleslaw LachDepartment of Pathology & Molecular Medicine, McMaster University, Hamilton Health Sciences, Hamilton General Hospital (Neuropathology), Hamilton, Ontario, Canada.
Barbara Connolly
Christian Wüthrich
Igor J Koralnik
McMaster University · CABeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
Translational applications of Progressive Multifocal Leukoencephalopathy studiesK24NS060950 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2008 to 2012
$707k
Cellular Immunity to JC Virus in AIDS-Associated Progressive Multifocal LeukoenceR56NS041198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2010 to 2010
$435k
NINDS NIH HHS K24 NS 060950NINDS NIH HHS K24 NS060950NINDS NIH HHS R01 NS 047029NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS074995NINDS NIH HHS R56 NS 041198NINDS NIH HHS R56 NS041198PHS HHS R01074995
6 · The paper itself

Abstract

An 84-year-old man with rheumatoid arthritis (RA) treated with methotrexate, developed progressive confusion and cerebellar symptoms, and died approximately 2 months later. Neuropathological examination revealed progressive multifocal leukoencephalopathy (PML) involving the cerebellum and brainstem. The affected tissues displayed intense infiltrations by CD8+ T-cells and microglia. JC virus was localized in oligodendroglia and cerebellar granule cells. This case illustrates unusual localization of inflammatory PML in a patient with RA treated with methotrexate.

Indexed as

Aged, 80 and overArthritis, RheumatoidCerebellumHumansInflammationLeukoencephalopathy, Progressive MultifocalMalePonscerebellar syndromedemyelinationmethotrexateprogressive multifocal leukoencephalopathyrheumatoid arthritis

Identifiers

PMID23683127
PMCPMC3783631
OpenAlexW1750263273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.