ArticleInsect molecular biology2013
A unique Y gene in the Asian malaria mosquito Anopheles stephensi encodes a small lysine-rich protein and is transcribed at the onset of embryonic development.
Article in Insect molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Neoclassical development of genetic sexing strains for insect pest and disease vector control.Insect science · 2026Review
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Selective targeting of biting females to control mosquito-borne infectious diseases.Trends in parasitology · 2022Review
- Estimating female malaria mosquito age by quantifying Y-linked genes in stored male spermatozoa.Scientific reports · 2022Article
- Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus.Insect biochemistry and molecular biology · 2020Article
- Article
- Pure early zygotic genes in the Asian malaria mosquito Anopheles stephensi.Parasites & vectors · 2018Article
- Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti.Parasites & vectors · 2018Article
- Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes.Parasites & vectors · 2018Review
- GUY1 confers complete female lethality and is a strong candidate for a male-determining factor ineLife · 2016Article
- Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Control of Mosquito-Borne Infectious Diseases: Sex and Gene Drive.Trends in parasitology · 2016Review
- Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi.Genome biology · 2014Article
- Site-specific genetic engineering of the Anopheles gambiae Y chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Insights into the preservation of the homomorphic sex-determining chromosome of Aedes aegypti from the discovery of a male-biased gene tightly linked to the M-locus.Genome biology and evolution · 2014Article
- De novo assembly and transcriptome analysis of the Mediterranean fruit fly Ceratitis capitata early embryos.PloS one · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In many organisms the Y chromosome initiates sex determination and regulates male fertility and mating behaviour. However, molecular characterization of Y genes is rare outside of a few model species because it is difficult to clone and analyse repeat-rich heterochromatic Y sequences. In insects, Y genes are only well characterized in a small number of Drosophila species. Here we report the discovery of GUY1 (gene unique to the Y), a gene unique to the Y chromosome in the Asian malaria mosquito, Anopheles stephensi, using an approach that compares Illumina sequences separately obtained from male and female genomic DNA. Experimental evidence confirmed that GUY1 is a single copy gene found only on the Y chromosome. GUY1 is transcribed at the very onset of zygotic transcription and encodes a small lysine-rich protein that forms two alpha helices and shows DNA-binding properties. Interestingly, three helix-loop-helix proteins are key factors that determine sex in the early embryo in Drosophila melanogaster. Single embryo analysis indicated that GUY1 is only transcribed in male embryos and that the GUY1 promoter is functional in the early embryos. GUY1 may be used as a paternally inherited molecular marker. Further investigation of GUY1 will contribute to the genetic approaches to control mosquito-borne diseases.
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