Evidence map›Paper›PMID 23682979›Full record

Trial reportBMC family practice2013

Rationale, design and organization of the delayed antibiotic prescription (DAP) trial: a randomized controlled trial of the efficacy and safety of delayed antibiotic prescribing strategies in the non-complicated acute respiratory tract infections in general practice.

Mariam de la Poza Abad, Gemma Mas Dalmau, Mikel Moreno Bakedano, Ana Isabel González González, Yolanda Canellas Criado, Silvia Hernández Anadón, Rafael Rotaeche del Campo, Pere Torán Monserrat, Antonio Negrete Palma, Guillem Pera and 5 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC family practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01363531 (Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01363531 phase4completednot on this map

Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2009 to 2012Enrolled405ConditionsPharyngitis, Acute Tonsillitis, Rhinosinusitis, Acute BronchitisArmsAntibiotic prescription strategies
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Immediate versus delayed versus no antibiotics for respiratory infections.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Delayed antibiotic prescriptions for respiratory infections.The Cochrane database of systematic reviews · 2017
    Pooled it
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Mariam de la Poza AbadCentro de Atención Primaria Doctor Carles Ribas, Barcelona, Spain.
Gemma Mas Dalmau
Mikel Moreno Bakedano
Ana Isabel González González
Yolanda Canellas Criado
Silvia Hernández Anadón
Rafael Rotaeche del Campo
Pere Torán Monserrat
Antonio Negrete Palma
Guillem Pera
Eulàlia Borrell Thió
Carl Llor
Paul Little
Pablo Alonso Coello
Delayed Antibiotic Prescription (DAP) Working Group
Iberoamerican Cochrane Centre · ESInstitut Universitari d'Investigació en Atenció Primària Jordi Gol · ESBadalona Serveis Assistencials · ESBroadmoor Hospital · GBConsorci d’Atenció Primària de Salut Barcelona Esquerra · ESMaresme Health Consortium · ESOsasun Sistemen Ikerketa Institutua · ES

Funding

Department of Health RP-PG-0407-10098
6 · The paper itself

Abstract

backgroundRespiratory tract infections are an important burden in primary care and it's known that they are usually self-limited and that antibiotics only alter its course slightly. This together with the alarming increase of bacterial resistance due to increased use of antimicrobials calls for a need to consider strategies to reduce their use. One of these strategies is the delayed prescription of antibiotics.

methodsMulticentric, parallel, randomised controlled trial comparing four antibiotic prescribing strategies in acute non-complicated respiratory tract infections. We will include acute pharyngitis, rhinosinusitis, acute bronchitis and acute exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (mild to moderate). The therapeutic strategies compared are: immediate antibiotic treatment, no antibiotic treatment, and two delayed antibiotic prescribing (DAP) strategies with structured advice to use a course of antibiotics in case of worsening of symptoms or not improving (prescription given to patient or prescription left at the reception of the primary care centre 3 days after the first medical visit). DISCUSSION: Delayed antibiotic prescription has been widely used in Anglo-Saxon countries, however, in Southern Europe there has been little research about this topic. The DAP trial wil evaluate two different delayed strategies in Spain for the main respiratory infections in primary care.

trial registrationThis trial is registered with ClinicalTrials.gov, number http://NCT01363531.

Indexed as

Professional PracticeAcute DiseaseAnti-Bacterial AgentsBacterial InfectionsDrug PrescriptionsHumansPractice Patterns, Physicians'Research DesignRespiratory Tract InfectionsTime FactorsAnti-Bacterial Agents

Identifiers

PMID23682979
PMCPMC3682866
OpenAlexW1997921984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.