Evidence map›Paper›PMID 23682867›Full record

ArticleAlcoholism, clinical and experimental research2013

Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking.

Timothy C Durazzo, David L Pennington, Thomas P Schmidt, Anderson Mon, Christoph Abé, Dieter J Meyerhoff

Abstract readMulticenter Study
In one paragraph

Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Brain Structure and Function in Recovery.Alcohol research : current reviews · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Heavy Alcohol Use and Age Effects on HIV-Associated Neurocognitive Function.Alcoholism, clinical and experimental research · 2019
    Article
  12. Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Timothy C DurazzoCenter for Imaging of Neurodegenerative Diseases (CIND) , San Francisco VA Medical Center, San Francisco, California; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.
David L Pennington
Thomas P Schmidt
Anderson Mon
Christoph Abé
Dieter J Meyerhoff
San Francisco VA Medical Center · USInstitute for Neurodegenerative Disorders · USUniversity of California System · US

Funding

The Biological Basis of Alcohol Induced Brain DamageR01AA010788 · NIAAA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MEYERHOFF, DIETER J · 1996 to 2016
$8.9M
The Neurobiological and Neurocognitive Consequences of Chronic Cigarette SmokingK01DA024136 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DURAZZO, TIMOTHY CRAIG · 2008 to 2012
$785k
NIAAA NIH HHS AA10788NIAAA NIH HHS R01 AA010788NIDA NIH HHS DA24136NIDA NIH HHS K01 DA024136
6 · The paper itself

Abstract

backgroundIncreasing age and chronic cigarette smoking are independently associated with adverse effects on multiple aspects of neurocognition in those seeking treatment for alcohol use disorders. However, the potential interactive effects of age and cigarette smoking on neurocognition in early abstinent alcohol-dependent individuals (ALC) have not investigated.

methodsCross-sectional performances of never-smoking healthy comparison participants (nvsCOM; n = 39) and 1-month-abstinent, treatment-seeking, never-smoking (nvsALC; n = 30), former-smoking (fsALC; n = 21), and actively smoking (asALC; n = 68) ALC were compared on a comprehensive neurocognitive battery. Domains of functioning evaluated were cognitive efficiency, executive functions, fine motor skills, general intelligence, learning and memory, processing speed, visuospatial functions and working memory. Participants were between 26 and 71 years of age at the time of assessment.

resultsasALC showed steeper age-related effects than nvsCOM on the domains of visuospatial learning, auditory-verbal memory, cognitive efficiency, executive functions, processing speed, and fine motor skills. In pairwise comparisons, fsALC and asALC performed more poorly than both nvsCOM and nvsALC on multiple domains; nvsCOM and nvsALC showed no significant differences. Domain scores for the ALC groups generally fell in the low-to-high-average range of functioning. A clinically significant level of impairment was apparent in only 25% of ALC participants on visuospatial learning, visuospatial memory, and fine motor skills domains. Measures of alcohol use or consumption were not significantly related to neurocognition in the ALC cohorts.

conclusionsThe age-related findings suggest that the combination of active chronic smoking and alcohol dependence in this 1-month-abstinent ALC cohort was associated with greater than normal age-related effects in multiple domains. In general, a low level of clinically significant impairment was observed in the alcohol-dependent participants. The findings from this study, in conjunction with previous research, strongly support smoking cessation interventions for those seeking treatment for alcohol and substance use disorders.

Indexed as

CognitionSubstance Abuse Treatment CentersAdultAgedAgingAlcoholismCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedSmokingTemperanceTime FactorsTreatment OutcomeAgeAlcohol DependenceAlcohol Use DisordersCigarette SmokingNeurocognition

Identifiers

PMID23682867
PMCPMC3749254
OpenAlexW2098279462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.