Evidence map›Paper›PMID 23682710›Full record

ArticleAnnals of the New York Academy of Sciences2013

Vitamin D: beyond bone.

Sylvia Christakos, Martin Hewison, David G Gardner, Carol L Wagner, Igor N Sergeev, Erica Rutten, Anastassios G Pittas, Ricardo Boland, Luigi Ferrucci, Daniel D Bikle

Open access · bronzeAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 4 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 4 syntheses or guidelines pooled it, 285 citations in OpenAlex.

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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 3 countries.

Sylvia ChristakosDepartment of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA.
Martin Hewison
David G Gardner
Carol L Wagner
Igor N Sergeev
Erica Rutten
Anastassios G Pittas
Ricardo Boland
Luigi Ferrucci
Daniel D Bikle
University of California, San Francisco · USCiro · NLMedical University of South Carolina · USNational Institute on Aging · USRutgers New Jersey Medical SchoolSouth Dakota State University · USTufts Medical Center · USUniversidad Nacional del Sur · ARUniversity of California, Los Angeles · US

Funding

Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PELLEGRINI, MATTEO · 2012 to 2016
$7.8M
Vitamin D and Calcium Homeostasis in Relation to Type 2 DiabetesR01DK076092 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2006 to 2015
$4.1M
Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
Role of vitamin D and calcium signaling in wound healingI01BX001066 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2011 to 2014
–
BLRD VA I01 BX001066NIAMS NIH HHS P50 AR063020NIAMS NIH HHS R01 AR050023NIDDK NIH HHS R01 DK076092
6 · The paper itself

Abstract

In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. However, the biological significance of the expression of the VDR in different tissues is not fully understood, and the role of vitamin D in extraskeletal health has been a matter of debate. This report summarizes recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging.

Indexed as

AdultAnimalsAutoimmune DiseasesCalcium SignalingCardiovascular DiseasesCognition DisordersDiabetes Mellitus, Type 2Disease Models, AnimalErythropoiesisFemaleHumansImmune SystemInfantLactationMaleMiceReceptors, CalcitriolVitamin D

Identifiers

PMID23682710
PMCPMC3717170
OpenAlexW1599765837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.