ReviewTranslational stroke research2013
In vivo animal stroke models: a rationale for rodent and non-human primate models.
Review in Translational stroke research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Early intervention with electrical stimulation reduces neural damage after stroke in non-human primates.Nature communications · 2025Article
- Effects of stem cell therapy on preclinical stroke.Open veterinary journal · 2025Review
- A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage.International journal of molecular sciences · 2023Article
- Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents.Acta pharmacologica Sinica · 2023Article
- A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies.Current neuropharmacology · 2022Review
- NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment.Magnetic resonance in medicine · 2021Article
- Development of a photochemical thrombosis investigation system to obtain a rabbit ischemic stroke model.Scientific reports · 2021Article
- Article
- Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia.Frontiers in cell and developmental biology · 2020Article
- Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies.International journal of nanomedicine · 2020Review
- Intra-arterial Drug Delivery to the Ischemic Brain in Rat Middle Cerebral Artery Occlusion Model.Bio-protocol · 2019Article
- Executive (dys)function after stroke: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone.Translational stroke research · 2017Article
- Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines.Translational stroke research · 2016Article
- NADPH Oxidase: A Potential Target for Treatment of Stroke.Oxidative medicine and cellular longevity · 2016Review
- Advancing research in regeneration and repair of the motor circuitry: non-human primate models and imaging scales as the missing links for successfully translating injectable therapeutics to the clinic.International journal of stem cell research and therapy · 2016Article
- White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.Experimental neurology · 2015Article
- Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model.Experimental neurology · 2015Article
- G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats.Experimental neurology · 2015Article
- A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy.Translational stroke research · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
On average, every four minutes an individual dies from a stroke, accounting for 1 out of every 18 deaths in the United States. Approximately 795,000 Americans have a new or recurrent stroke each year, with just over 600,000 of these being first attack [1]. There have been multiple animal models of stroke demonstrating that novel therapeutics can help improve the clinical outcome. However, these results have failed to show the same outcomes when tested in human clinical trials. This review will discuss the current in vivo animal models of stroke, advantages and limitations, and the rationale for employing these animal models to satisfy translational gating items for examination of neuroprotective, as well as neurorestorative strategies in stroke patients. An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.