ArticleJournal of applied crystallography2013
The current approach to initial crystallization screening of proteins is under-sampled.
Article in Journal of applied crystallography, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The FUSION protein crystallization screen.Journal of applied crystallography · 2022Article
- Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology.Journal of visualized experiments : JoVE · 2018Article
- Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants.Nature chemical biology · 2017Article
- Protein crystallization screens developed at the MRC Laboratory of Molecular Biology.Drug discovery today · 2016Review
- Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.Acta crystallographica. Section D, Biological crystallography · 2015Article
- The MORPHEUS II protein crystallization screen.Acta crystallographica. Section F, Structural biology communications · 2015Article
- Progress in macromolecular crystallography depends on further miniaturization of crystallization experiments.Drug discovery today · 2014Article
- Carboxylic acids in crystallization of macromolecules: learning from successful crystallization experiments.Journal of structural and functional genomics · 2014Article
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Abstract
Protein crystallization conditions that resulted in crystal structures published by scientists at the MRC Laboratory of Molecular Biology (MRC-LMB, Cambridge, UK) have been analysed. It was observed that the more often a crystallization reagent had been used to formulate the initial conditions, the more often it was found in the reported conditions that yielded diffraction quality crystals. The present analysis shows that, despite the broad variety of reagents, they have the same impact overall on the yield of crystal structures. More interestingly, the correlation implies that, although the initial crystallization screen may be considered very large, it is an under-sampled combinatorial approach.
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