Evidence map›Paper›PMID 23682163›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2013

Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial.

Thomas J Povsic, Richard Sloane, Jiying Zhou, Carl F Pieper, Megan P Pearson, Eric D Peterson, Jennifer B Green, Harvey J Cohen, Miriam C Morey

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00594399 (Enhancing Fitness in Older Overweight Vets With Impaired Fasting Glucose), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00594399 phase2 / phase3completednot on this map

Enhancing Fitness in Older Overweight Vets With Impaired Fasting Glucose

TypeinterventionalSponsorUS Department of Veterans AffairsRan2008 to 2011Enrolled302ConditionsImpaired Glucose Tolerance, Obesity, DiabetesArmsPhysical Activity Counseling
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
    Trial
  3. Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas J PovsicBox 103208, Duke University Medical Center, Durham, NC 27708. thomas.povsic@duke.edu.
Richard Sloane
Jiying Zhou
Carl F Pieper
Megan P Pearson
Eric D Peterson
Jennifer B Green
Harvey J Cohen
Miriam C Morey

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
RENEW Research-out to ENhancE Wellness Older SurvivorsR01CA106919 · NCI · DUKE UNIVERSITY · PI DEMARK-WAHNEFRIED, WENDY · 2004 to 2007
$2.1M
NCI NIH HHS CA106919NIA NIH HHS 5P30AG028716NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

backgroundAging is marked by a decline in physical function. Although the biological underpinnings for this remain unclear, loss of regenerative capacity has been proposed as one cause of the loss of physical function that occurs over time. The quantity of circulating progenitor cells (CPCs) may be one reflection of regenerative capability. We sought to determine whether certain specific CPC subpopulations were associated with physical function.

methodsBaseline CPCs were measured in 129 randomized participants in the Enhanced Fitness clinical trial based on the cell surface markers CD34, CD133, CD146, and CD14 and aldehyde dehydrogenase (ALDH) activity. Physical function was assessed using usual and rapid gait speed, 6-minute walk distance, chair stand time, and balance time.

resultsLow counts of early angiogenic CPCs identified as CD34(+), CD34(+)CD133(+), and ALDH-bright (ALDH(br)) cells were associated with low usual gait speed (p < .005, p < .001, and p < .007), rapid gait speed (p < .001, p < .003, and p < .001), and 6-minute walking distance (all comparisons p < .001), and longer time required to complete five chair stands (p < .006, p < .002, and p < .004). CPC counts of mature endothelial or monocytic markers were not associated with physical function.

conclusionsThe numbers of CD34(+) and ALDH(br) CPCs are significantly lower in patients with impaired physical function. Further studies are needed to determine the underlying causes for this association.

Indexed as

AgedAged, 80 and overAgingAldehyde DehydrogenaseAntigens, CDBiomarkersEndothelial CellsExercise ToleranceGeriatric AssessmentGlucose IntoleranceHumansMaleMiddle AgedMonocytesPhysical FitnessPilot ProjectsAldehyde DehydrogenaseAntigens, CDBiomarkersAgingEndothelial progenitor cellsPhysical functionPhysical performanceProgenitor cells biology.

Identifiers

PMID23682163
PMCPMC3814238

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.