ArticleInflammation2013
Predicting sputum eosinophilia in exacerbations of COPD using exhaled nitric oxide.
Article in Inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis.Annals of medicine · 2021Pooled it
- Lack of Association between Inhaled Corticosteroid Use Based on the Exhaled Nitric Oxide and Acute Exacerbation of Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2024Article
- Exploring Mechanisms in COPD: Time for Biomarker Reappraisal?Journal of clinical medicine · 2023Article
- Fractional nitric oxide measurement in exhaled air (FeNO): perspectives in the management of respiratory diseases.Therapeutic advances in chronic disease · 2023Review
- Blood Eosinophils and Exhaled Nitric Oxide: Surrogate Biomarkers of Airway Eosinophilia in Stable COPD and Exacerbation.Biomedicines · 2022Review
- Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma.The Korean journal of internal medicine · 2021Review
- Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD.The Journal of allergy and clinical immunology · 2020Article
- Relationship of Blood Eosinophils with Fractional Exhaled Nitric Oxide and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations.BMC pulmonary medicine · 2020Article
- Role of the Bronchodilator Test Defined by the Forced Vital Capacity in Chronic Obstructive Pulmonary Disease Phenotyping.International journal of chronic obstructive pulmonary disease · 2020Article
- Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Exhaled Nitric Oxide in Patients with Stable Chronic Obstructive Pulmonary Disease: Clinical Implications of the Use of Inhaled Corticosteroids.Tuberculosis and respiratory diseases · 2020Article
- Clinical Practice Guidelines for Diagnosis and Management of Cough-Chinese Thoracic Society (CTS) Asthma Consortium.Journal of thoracic disease · 2018Review
- Treatment of chronic obstructive pulmonary disease in patients with different fractional exhaled nitric oxide levels.Medicine · 2018Observational
- Shall We Focus on the Eosinophil to Guide Treatment with Systemic Corticosteroids during Acute Exacerbations of COPD?: PRO.Medical sciences (Basel, Switzerland) · 2018Review
- Emerging pharmaceutical therapies for COPD.International journal of chronic obstructive pulmonary disease · 2017Review
- Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- Benralizumab: a unique IL-5 inhibitor for severe asthma.Journal of asthma and allergy · 2016Review
- Comparison of the clinical characteristics and treatment outcomes of patients requiring hospital admission to treat eosinophilic and neutrophilic exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Exhaled nitric oxide and disease progression in chronic obstructive pulmonary disease.Journal of thoracic disease · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fractional exhaled nitric oxide (FENO) may be a pulmonary biomarker in chronic obstructive pulmonary disease (COPD). In this prospective study, the relationship between FENO and airway inflammation was assessed in COPD exacerbations. FENO and lung function were measured, and sputum was collected from 49 ex-smoking COPD patients, first at the time of hospital admission and again at discharge following treatment. There was a significant positive correlation between the percentage of sputum eosinophils and FENO concentrations, both at exacerbation (r = 0.593, p < 0.001) and discharge (r = 0.337, p = 0.044). The increase in forced expiratory volume in one second (FEV(1)) after treatment was greater in patients with sputum eosinophilia (ΔFEV(1) 0.35 ± 0.12 vs. 0.13 ± 0.04 L, p = 0.046), and FENO was a strong predictor of sputum eosinophilia (area under the receiver operating characteristic curve, 0.89). The optimum cut point was 19 parts per billion (sensitivity: 90 %; specificity: 74 %). Our data suggest that FENO is a good surrogate marker of eosinophilic inflammation in COPD patients with exacerbations.
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