ArticleInternational journal of geriatric psychiatry2014
Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study.
Article in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Clinical outcomes of antihypertensive medication use in people with dementia: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Assessment of Reported Comparative Effectiveness and Safety of Atypical Antipsychotics in the Treatment of Behavioral and Psychological Symptoms of Dementia: A Network Meta-analysis.JAMA network open · 2019Pooled it
- Trial
- Longitudinal associations of cardiovascular-kidney-metabolic syndrome with midlife or late-life mental disorders and dementia, and the mediating role of metabolomic signature.Communications medicine · 2026Article
- Neurobiological and therapeutic landmarks of depression associated with Alzheimer's disease dementia.Frontiers in aging neuroscience · 2025Review
- There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- The symbiotic experiences of residents with and without dementia co-living in Taiwan's long-term care facilities: a phenomenological study.BMC geriatrics · 2024Article
- Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities.Nature reviews. Neurology · 2022Review
- Vascular Dementia and Underlying Sex Differences.Frontiers in aging neuroscience · 2021Review
- Blood pressure, antihypertensive medication and neuropsychiatric symptoms in older people with dementia: The COSMOS study.International journal of geriatric psychiatry · 2021Article
- Neuropsychiatric symptoms in severe dementia: Associations with specific cognitive domains the Cache County Dementia Progression Study.International journal of geriatric psychiatry · 2019Article
- Caregiver-Care Recipient Relationship Closeness is Associated With Neuropsychiatric Symptoms in Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- Neuropsychiatric Profile in Early Versus Late Onset Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2018Article
- Hypertension and Neuropsychiatric Symptoms in Patients with Drug-Naïve Alzheimer's Disease.Dementia and neurocognitive disorders · 2017Article
- Obesity and Co-morbid Conditions Are Associated with Specific Neuropsychiatric Symptoms in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Low Prevalence and Clinical Effect of Vascular Risk Factors in Early-Onset Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Article
- Lewy Bodies, Vascular Risk Factors, and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer Pathology, are Associated with Development of Psychosis in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2016Article
- Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease.Neuroscience and biobehavioral reviews · 2015Review
- The Cache County Study on Memory in Aging: factors affecting risk of Alzheimer's disease and its progression after onset.International review of psychiatry (Abingdon, England) · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveKnowledge of potentially modifiable risk factors for neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) is important. This study longitudinally explores modifiable vascular risk factors for NPS in AD.
methodsParticipants enrolled in the Cache County Study on Memory in Aging with no dementia at baseline were subsequently assessed over three additional waves, and those with incident (new onset) dementia were invited to join the Dementia Progression Study for longitudinal follow-up. A total of 327 participants with incident AD were identified and assessed for the following vascular factors: atrial fibrillation, hypertension, diabetes mellitus, angina, coronary artery bypass surgery, myocardial infarction, cerebrovascular accident, and use of antihypertensive or diabetes medicines. A vascular index (VI) was also calculated. NPS were assessed over time using the Neuropsychiatric Inventory (NPI). Affective and Psychotic symptom clusters were assessed separately. The association between vascular factors and change in NPI total score was analyzed using linear mixed model and in symptom clusters using a random effects model.
resultsNo individual vascular risk factors or the VI significantly predicted change in any individual NPS. The use of antihypertensive medications more than four times per week was associated with higher total NPI and Affective cluster scores.
conclusionsUse of antihypertensive medication was associated with higher total NPI and Affective cluster scores. The results of this study do not otherwise support vascular risk factors as modifiers of longitudinal change in NPS in AD.
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Registered trials
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