Evidence map›Paper›PMID 23681659›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2013

Organelle asymmetry for proper fitness, function, and fate.

Dorothy A Lerit, Jeremy T Smyth, Nasser M Rusan

Abstract readReview
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Asymmetry of centrosomes inMolecular biology of the cell · 2025
    Article
  2. Article
  3. Review
  4. Coordinating Proliferation, Polarity, and Cell Fate in theFrontiers in cell and developmental biology · 2020
    Review
  5. It takes two (centrioles) to tango.Reproduction (Cambridge, England) · 2019
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Cell Fate Decision Making through Oriented Cell Division.Journal of developmental biology · 2015
    Article
  11. When fate follows age: unequal centrosomes in asymmetric cell division.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Review
  12. Live imaging of Drosophila larval neuroblasts.Journal of visualized experiments : JoVE · 2014
    Article
  13. Polo-like kinases: structural variations lead to multiple functions.Nature reviews. Molecular cell biology · 2014
    Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dorothy A LeritCell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jeremy T Smyth
Nasser M Rusan

Funding

Regulation of Centrosome Asymmetry in Stem CellsZIAHL006126 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI RUSAN, NASSER · 2011 to 2025
$19.4M
Intramural NIH HHS ZIA HL006126
6 · The paper itself

Abstract

During cellular division, centrosomes are tasked with building the bipolar mitotic spindle, which partitions the cellular contents into two daughter cells. While every cell will receive an equal complement of chromosomes, not every organelle is symmetrically passaged to the two progeny in many cell types. In this review, we highlight the conservation of nonrandom centrosome segregation in asymmetrically dividing stem cells, and we discuss how the asymmetric function of centrosomes could mediate nonrandom segregation of organelles and mRNA. We propose that such a mechanism is critical for insuring proper cell fitness, function, and fate.

Indexed as

Cell LineageAnimalsHumansMicrotubule-Organizing CenterOrganellesStem Cells

Identifiers

PMID23681659
PMCPMC4121668

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.