ArticleClinical research in cardiology : official journal of the German Cardiac Society2013
Erectile dysfunction may be the first clinical sign of insulin resistance and endothelial dysfunction in young men.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association of insulin resistance surrogate indices and erectile dysfunction: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Investigating the role of acute mental stress on endothelial dysfunction: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Pooled it
- Immune-mediated skin diseases and erectile dysfunction: mechanisms and multidisciplinary management.Frontiers in immunology · 2026Review
- From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management.Frontiers in cell and developmental biology · 2026Review
- Associations of different insulin resistance indices with the erectile dysfunction incidence: a cross-sectional analysis of the NHANES 2001-2004.Translational andrology and urology · 2025Article
- Association between the C-reactive protein-triglyceride glucose index and erectile dysfunction in US males: results from NHANES 2001-2004.International journal of impotence research · 2025Article
- Review
- Association between different insulin resistance surrogates and erectile dysfunction in non-diabetic men: a large population-based study.BMC public health · 2025Article
- The Association between the Gut Microbiota and Erectile Dysfunction.The world journal of men's health · 2024Article
- Associations between Erectile Dysfunction and Vascular Parameters: A Systematic Review and Meta-Analysis.The world journal of men's health · 2024Article
- Erectile Dysfunction in Individuals with Type 1 Diabetes is Associated with Long-term Metabolic Control and Diabetic Complications: A Cross-Sectional Study.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022Article
- A higher TyG index is related with a higher prevalence of erectile dysfunction in males between the ages 20-70 in the United States, according to a cross-sectional research.Frontiers in endocrinology · 2022Article
- The Association Between FGF21 and Diabetic Erectile Dysfunction: Evidence from Clinical and Animal Studies.Frontiers in endocrinology · 2022Article
- What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?Journal of diabetes investigation · 2020Article
- Prevalence of thrombophilic disorders in takotsubo patients: the (ThROmbophylia in TAkotsubo cardiomyopathy) TROTA study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Effects of prolonged ingestion of epigallocatechin gallate on diabetes type 1-induced vascular modifications in the erectile tissue of rats.International journal of impotence research · 2016Article
- Erectile dysfunction.Nature reviews. Disease primers · 2016Review
- Article
- Understanding and targeting the Rho kinase pathway in erectile dysfunction.Nature reviews. Urology · 2014Review
- Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study is to investigate the possible underlying pathogenesis of erectile dysfunction (ED) without well-known etiology in young men under the age of 40 years.
methods192 patients and 33 normal controls were enrolled. ED was evaluated by using the International Index of Erectile Function-5 (IIEF-5) questionnaire. Traditional cardiovascular risk factors, hormone levels, and vascular parameters were measured. Insulin resistance (IR) was measured by homeostasis model assessment (HOMA).
resultsPatients with ED had significantly higher levels of systolic blood pressure (SBP), high-sensitivity C-reactive protein (Hs-CRP), high Insulin resistance index (HOMA-IR) and carotid intima-media thickness (IMT), compared with controls. The brachial artery endothelium-dependent flow-mediated vasodilation (FMD) values were significantly lower in ED patients. By multivariate logistic regression analysis, FMD, SBP, Hs-CRP and HOMA-IR were significantly associated with ED. In receiver-operating characteristic (ROC) analysis, FMD was a significant predictor of ED (area under the curve (AUC) 0.933, p < 0.001). The cutoff value of FMD <10.4 % had sensitivity of 81.3 % and specificity of 100 %. HOMA-IR was also proven to be predictor of ED (AUC of HOMA-IR 0.759, p < 0.001).
conclusionsED may be the first clinical sign of endothelial dysfunction and a clinical marker of cardiovascular and metabolic diseases. Subclinical endothelial dysfunction and insulin resistance may be the underlying pathogenesis of ED in young patients without well-known etiology. Measurement of FMD, HOMA-IR can improve our ability to predict and treat ED, as well as subclinical cardiovascular disease early in young men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.