Trial reportExperimental brain research2013
Dopamine, norepinephrine, and the management of sensorimotor bindings: individual differences in updating of stimulus-response episodes are predicted by DAT1, but not DBH5'-ins/del.
Trial report in Experimental brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Perception-Action Integration Is Modulated by the Catecholaminergic System Depending on Learning Experience.The international journal of neuropsychopharmacology · 2021Trial
- Towards an Ideology-Free, Truly Mechanistic Health Psychology.International journal of environmental research and public health · 2021Article
- Perception-action integration in young age-A cross-sectional EEG study.Developmental cognitive neuroscience · 2021Article
- On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding.Human brain mapping · 2021Article
- Rumination impairs the control of stimulus-induced retrieval of irrelevant information, but not attention, control, or response selection in general.Psychological research · 2020Article
- Gilles de la Tourette Syndrome-A Disorder of Action-Perception Integration.Frontiers in neurology · 2020Review
- Decoding Stimulus-Response Representations and Their Stability Using EEG-Based Multivariate Pattern Analysis.Cerebral cortex communications · 2020Article
- MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory.Frontiers in human neuroscience · 2018Article
- The effect of gamma-enhancing binaural beats on the control of feature bindings.Experimental brain research · 2017Article
- People are different: tyrosine's modulating effect on cognitive control in healthy humans may depend on individual differences related to dopamine function.Frontiers in psychology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence suggests that the flexibility of managing (creating and updating) stimulus-response bindings is driven by the dopaminergic system. Given that striatal dopamine (DA) plays a crucial role in the updating of working memory, the present study tested whether individual differences in the efficiency of updating stimulus-response episodes (event files) are predicted by differences in genetic predisposition related to the efficiency of the striatal dopaminergic pathway. In view of contrasting claims that stimulus-response binding is related to norepinephrine, we also considered genetic predispositions regarding noradrenergic pathways. In a sample of 100 healthy adults, we studied whether the degree to which stimulus-response bindings affect ongoing performance is predicted by polymorphisms of the dopamine transporter gene (DAT1, associated with striatal DA levels) and DBH5'-ins/del (strongly correlated with dopamine beta-hydroxylase, the enzyme catalyzing the dopamine-norepinephrine conversion). The performance of 9-repeat carriers of the DAT1 gene was more affected by stimulus-response bindings than the performance of 10/10 homozygotes was, while DBH5'-ins/del polymorphism was not related to performance. This outcome pattern suggests a crucial role of the nigrostriatal dopaminergic pathway in the flexible management of stimulus-response episodes, whereas norepinephrine does not seem to play a role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.