ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2013
Octopamine modulates activity of neural networks in the honey bee antennal lobe.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (Ecology and evolution · 2025Article
- Plasticity in inhibitory networks improves pattern separation in early olfactory processing.Communications biology · 2025Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations.Cell reports · 2021Article
- Survey of neurotransmitter receptor gene expression into and out of parental care in the burying beetleEcology and evolution · 2021Article
- Visuo-Motor Feedback Modulates Neural Activities in the Medulla of the Honeybee,The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Learning-dependent plasticity in the antennal lobe improves discrimination and recognition of odors in the honeybee.Cell and tissue research · 2021Review
- Experience-dependent tuning of early olfactory processing in the adult honey bee,The Journal of experimental biology · 2020Article
- Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain.The Journal of experimental biology · 2019Article
- Olfactory learning without the mushroom bodies: Spiking neural network models of the honeybee lateral antennal lobe tract reveal its capacities in odour memory tasks of varied complexities.PLoS computational biology · 2017Article
- Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (Frontiers in systems neuroscience · 2017Article
- Learning about natural variation of odor mixtures enhances categorization in early olfactory processing.The Journal of experimental biology · 2016Article
- Learning modifies odor mixture processing to improve detection of relevant components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Olfactory coding in the insect brain: data and conjectures.The European journal of neuroscience · 2014Review
- Octopaminergic gene expression and flexible social behaviour in the subsocial burying beetle Nicrophorus vespilloides.Insect molecular biology · 2014Article
- The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Biogenic amines are associated with worker task but not patriline in the leaf-cutting ant Acromyrmex echinatior.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal plasticity allows an animal to respond to environmental changes by modulating its response to stimuli. In the honey bee (Apis mellifera), the biogenic amine octopamine plays a crucial role in appetitive odor learning, but little is known about how octopamine affects the brain. We investigated its effect in the antennal lobe, the first olfactory center in the brain, using calcium imaging to record background activity and odor responses before and after octopamine application. We show that octopamine increases background activity in olfactory output neurons, while reducing average calcium levels. Odor responses were modulated both upwards and downwards, with more odor response increases in glomeruli with negative or weak odor responses. Importantly, the octopamine effect was variable across glomeruli, odorants, odorant concentrations and animals, suggesting that the octopaminergic network is shaped by plasticity depending on an individual animal's history and possibly other factors. Using RNA interference, we show that the octopamine receptor AmOA1 (homolog of the Drosophila OAMB receptor) is involved in the octopamine effect. We propose a network model in which octopamine receptors are plastic in their density and located on a subpopulation of inhibitory neurons in a disinhibitory pathway. This would improve odor-coding of behaviorally relevant, previously experienced odors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.