Evidence map›Paper›PMID 23681082›Full record

ReviewRespiratory physiology & neurobiology2013

Clinical consequences of altered chemoreflex control.

Maria Plataki, Scott A Sands, Atul Malhotra

Abstract readReview
In one paragraph

Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Pathophysiology of central sleep apneas.Sleep & breathing = Schlaf & Atmung · 2016
    Review
  12. Review
  13. Obstructive Sleep Apnea and Kidney Disease: A Potential Bidirectional Relationship?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015
    Review
  14. Neurology and altitude illness.Neurology. Clinical practice · 2015
    Article
  15. Article
  16. Clinical challenges to ventilatory control.Respiratory physiology & neurobiology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria PlatakiDepartment of Internal Medicine, Bridgeport Hospital, Yale New Haven Health, Bridgeport, CT, USA.
Scott A Sands
Atul Malhotra

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAMBERLIN, NANCY L · 2010 to 2019
$25.1M
The MIND USA StudyR01AG035117 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELY, E WESLEY · 2011 to 2016
$7.3M
Sub Project 2UM1HL108724 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LORING, STEPHEN H, TALMOR, DANIEL STUART · 2012 to 2014
$4.6M
Obstructive Sleep Apnea Increases Cardiovascular Risk in Type 2 DiabetesR01HL110350 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PATEL, SANJAY R, VEVES, ARISTIDIS · 2012 to 2016
$4.0M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Mechanisms Underlying the Aging Predisposition to Obstructive Sleep ApneaR01HL090897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2009 to 2012
$1.8M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
NCRR NIH HHS UL1 RR025758NCRR NIH HHS UL1 RR 025758-01NHLBI NIH HHS K24 HL093218NHLBI NIH HHS NIH 1 P01 HL 095491NHLBI NIH HHS NIH K24 HL 093218NHLBI NIH HHS NIH R01 HL085188NHLBI NIH HHS NIH R01 HL090897NHLBI NIH HHS NIH R01HL110350NHLBI NIH HHS NIH UM1HL108724NHLBI NIH HHS P01 HL095491NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL090897NHLBI NIH HHS R01 HL110350NHLBI NIH HHS UM1 HL108724NIA NIH HHS NIH R01- AG035117NIA NIH HHS R01 AG035117
6 · The paper itself

Abstract

Control of ventilation dictates various breathing patterns. The respiratory control system consists of a central pattern generator and several feedback mechanisms that act to maintain ventilation at optimal levels. The concept of loop gain has been employed to describe its stability and variability. Synthesizing all interactions under a general model that could account for every behavior has been challenging. Recent insight into the importance of these feedback systems may unveil therapeutic strategies for common ventilatory disturbances. In this review we will address the major mechanisms that have been proposed as mediators of some of the breathing patterns in health and disease that have raised controversies and discussion on ventilatory control over the years.

Indexed as

Carbon DioxideChemoreceptor CellsCheyne-Stokes RespirationHumansHypercapniaOxygenRespiratory MechanicsSleep Apnea SyndromesCarbon DioxideOxygenCheyne–StokesExercise hyperpneaHigh altitudeLoop gainLungOxygen induced hypercapniaSleep apnea

Identifiers

PMID23681082
PMCPMC4336771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.