ArticleMolecules (Basel, Switzerland)2013
Synthesis and characterization of oil-chitosan composite spheres.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Antimicrobial activity of chitosan, alginate, pectin, and cellulose-based biopolymer composites with silver, copper oxide, and zinc oxide nanoparticles.RSC advances · 2025Review
- Synthesis of Chitosan-Silver Nanoparticle Composite Spheres and Their Antimicrobial Activities.Polymers · 2021Article
- Chitosan-Based Anti-Oxidation Delivery Nano-Platform: Applications in the Encapsulation of DHA-Enriched Fish Oil.Marine drugs · 2021Article
- Nutraceutical Vegetable Oil Nanoformulations for Prevention and Management of Diseases.Nanomaterials (Basel, Switzerland) · 2020Review
- Synthesis and anti-fungal effect of silver nanoparticles-chitosan composite particles.International journal of nanomedicine · 2015Article
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Authors and funding
10 authors.
Funding
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Abstract
Oil-chitosan composite spheres were synthesized by encapsulation of sunflower seed oil in chitosan droplets, dropping into NaOH solution and in situ solidification. Hydrophilic materials (i.e., iron oxide nanoparticles) and lipophilic materials (i.e., rhodamine B or epirubicin) could be encapsulated simultaneously in the spheres in a one step process. The diameters of the prepared spheres were 2.48 ± 0.11 mm (pure chitosan spheres), 2.31 ± 0.08 mm (oil-chitosan composites), 1.49 ± 0.15 mm (iron-oxide embedded oil-chitosan composites), and 1.69 ± 0.1 mm (epirubicin and iron oxide encapsulated oil-chitosan composites), respectively. Due to their superparamagnetic properties, the iron-oxide embedded oil-chitosan composites could be guided by a magnet. A lipophilic drug (epirubicin) could be loaded in the spheres with encapsulation rate measured to be 72.25%. The lipophilic fluorescent dye rhodamine B was also loadable in the spheres with red fluorescence being observed under a fluorescence microscope. We have developed a novel approach to an in situ process for fabricating oil-chitosan composite spheres with dual encapsulation properties, which are potential multifunctional drug carriers.
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