ArticleNature reviews. Drug discovery2013
Quantifying biased agonism: understanding the links between affinity and efficacy.
Article in Nature reviews. Drug discovery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.Nature communications · 2019Article
- An intact model for quantifying functional selectivity.Scientific reports · 2019Article
- An evaluation of the operational model when applied to quantify functional selectivity.British journal of pharmacology · 2018Article
- Biased signalling: from simple switches to allosteric microprocessors.Nature reviews. Drug discovery · 2018Review
- Pancreatic islet inflammation: an emerging role for chemokines.Journal of molecular endocrinology · 2017Review
- Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach.Scientific reports · 2017Article
- Superagonism at G protein-coupled receptors and beyond.British journal of pharmacology · 2016Review
- Article
- Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity.Scientific reports · 2016Article
- Biased agonism: An emerging paradigm in GPCR drug discovery.Bioorganic & medicinal chemistry letters · 2016Review
- A novel method for analyzing extremely biased agonism at G protein-coupled receptors.Molecular pharmacology · 2015Article
- Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.The Journal of pharmacology and experimental therapeutics · 2015Article
- Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands.British journal of pharmacology · 2015Review
- Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Biochemical pharmacology · 2014Article
- Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).The Journal of biological chemistry · 2014Article
- Recent developments in biased agonism.Current opinion in cell biology · 2014Review
- Measurements of ligand bias and functional affinity.Nature reviews. Drug discovery · 2013Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
23681006What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.