Evidence map›Paper›PMID 23680681›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2013

Predictors of acute stroke mimics in 8187 patients referred to a stroke service.

José G Merino, Marie Luby, Richard T Benson, Lisa A Davis, Amie W Hsia, Lawrence L Latour, John K Lynch, Steven Warach

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06045455 (The Importance of Multimodal CT Examination in Stroke Mimics Diagnosis), which is not on this map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06045455 recruitingnot on this mapstarted 2023, after this paper: background citation

The Importance of Multimodal CT Examination in Stroke Mimics Diagnosis: a Prospective Observational Multicenter Study

TypeobservationalSponsorUniversity Hospital OstravaRan2023 to 2026Enrolled3,000ConditionsStroke MimicsArmsMultimodal brain CT, Magnetic resonance imaging (MRI)
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 179 citations in OpenAlex.

  1. Trial
  2. Review
  3. Observational
  4. Article
  5. Observational
  6. CT perfusion in the acute setting: a useful tool in the differential diagnosis of aphasic syndromes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Imaging of Status Epilepticus.Journal of clinical medicine · 2025
    Review
  12. Review
  13. Observational
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

José G MerinoSection on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland; Johns Hopkins Community Physicians, Bethesda, Maryland; Suburban Hospital Stroke Center, Bethesda, Maryland. Electronic address: jmerino3@jhmi.edu.
Marie Luby
Richard T Benson
Lisa A Davis
Amie W Hsia
Lawrence L Latour
John K Lynch
Steven Warach
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USMedStar Washington Hospital Center · US

Funding

NOVEL INSIGHTS INTO CEREBRAL ISCHEMIC PATHOPHYSIOLOGY IN HUMANSZIANS003043 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2009 to 2025
$19.5M
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

backgroundSome patients seen by a stroke team do not have cerebrovascular disease but a condition that mimics stroke. The purpose of this study was to determine the rate and predictors of stroke mimics in a large sample.

methodsThis is an analysis of data from consecutive patients seen by the National Institutes of Health Stroke Program over 10 years. Data were collected prospectively as a quality improvement initiative. Patients with a cerebrovascular event or a stroke mimic were compared with the Student t or Pearson chi-square test as appropriate, and logistic regression was done to identify independent predictors.

resultsThe analysis included 8187 patients: 30% had a stroke mimic. Patients with a stroke mimic were younger, and the proportion of patients with a stroke mimic was higher among women, patients without any risk factors, those seen as a code stroke or who arrived to the emergency department via personal vehicle, and those who had the onset of symptoms while inpatients. The proportion of patients with a stroke mimic was marginally higher among African-Americans than Caucasians. Factors associated with the greatest odds of having a stroke mimic in the logistic regression were lack of a history of hypertension, atrial fibrillation or hyperlipidemia.

conclusionsOne third of the patients seen by a stroke team over 10 years had a stroke mimic. Factors associated with a stroke mimic may be ascertained by an emergency physician before calling the stroke team.

Indexed as

National Institutes of Health (U.S.)Referral and ConsultationAgedAge FactorsBlack or African AmericanChi-Square DistributionComorbidityDiagnosis, DifferentialEmergency Medical ServicesFemaleHumansLogistic ModelsMaleOdds RatioPatient Care TeamPredictive Value of TestsAcute strokediagnosisemergency medicinestroke mimics

Identifiers

PMID23680681
PMCPMC3812364
OpenAlexW2044903062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.