Evidence map›Paper›PMID 23680305›Full record

ReviewCurrent opinion in biotechnology2013

Matrix-based gene delivery for tissue repair.

Cynthia Cam, Tatiana Segura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Gene Delivery to Chondrocytes.Advances in experimental medicine and biology · 2023
    Article
  3. Gene therapy to enhance angiogenesis in chronic wounds.Molecular therapy. Nucleic acids · 2022
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. MicroRNA delivery for regenerative medicine.Advanced drug delivery reviews · 2015
    Review
  12. Article
  13. Tissue engineering for bone regeneration and osseointegration in the oral cavity.Dental materials : official publication of the Academy of Dental Materials · 2015
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cynthia CamDepartment of Bioengineering, University of California, Los Angeles, United States.
Tatiana Segura

Funding

Hydrogels for Local Gene Delivery and Therapeutic AngiogenesisR01HL110592 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2011 to 2015
$1.8M
NHLBI NIH HHS R01 HL110592
6 · The paper itself

Abstract

Scaffolds for tissue repair must provide structural and biochemical cues to initiate the complex cascade of events that lead to proper tissue formation. Incorporating genes into these scaffolds is an attractive alternative to protein delivery since gene delivery can be tunable to any DNA sequence and genes utilize the cells' machinery to continuously produce therapeutic proteins, leading to longer lasting transgene expression and activation of autocrine and paracrine signaling that are not activated with bulk protein delivery. In this review, we discuss the importance of scaffold design and the impact of its design parameters (e.g. material, architecture, vector incorporation, biochemical cue presentation) on transgene expression and tissue repair.

Indexed as

Gene Transfer TechniquesAbsorptionAnimalsDNAGenetic TherapyGenetic VectorsHumansImmobilized Nucleic AcidsTransfectionTransgenesWound HealingDNAImmobilized Nucleic Acids

Identifiers

PMID23680305
PMCPMC3770770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.