Trial reportBMC public health2013
The saving and empowering young lives in Europe (SEYLE) randomized controlled trial (RCT): methodological issues and participant characteristics.
Trial report in BMC public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00906620 (Saving and Empowering Young Lives in Europe in Israel, Evaluation, Intervention and Prevention), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Saving and Empowering Young Lives in Europe in Israel, Evaluation, Intervention and Prevention
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions.BMJ open · 2024Pooled it
- A Systematic Review of School-Based Suicide Prevention Interventions for Adolescents, and Intervention and Contextual Factors in Prevention.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- Interventions for self-harm in children and adolescents.The Cochrane database of systematic reviews · 2015Pooled it
- The impact of school-based screening on service use in adolescents at risk for mental health problems and risk-behaviour.European child & adolescent psychiatry · 2023Trial
- Direct Self-Injurious Behavior (D-SIB) and Life Events among Vocational School and High School Students.International journal of environmental research and public health · 2018Trial
- Association between oral microbiota and suicidal ideation among vocational high school students in China.BMC oral health · 2026Article
- Youth Aware of Mental Health for Danish School Adolescents: Study Protocol for a Cluster-Randomized Feasibility Pilot Trial.International journal of methods in psychiatric research · 2026Article
- Suicide prevention program on suicidal behaviors and mental wellbeing among school aged adolescents: a scoping review.Frontiers in public health · 2025Article
- Twelve-month service use, suicidality and mental health problems of European adolescents after a school-based screening for current suicidality.European child & adolescent psychiatry · 2022Article
- Measuring Mental Wellness of Adolescents: A Systematic Review of Instruments.Frontiers in psychology · 2022Review
- Relationship between Family Function, Anxiety, and Quality of Life for Older Adults with Hypertension in Low-Income Communities.International journal of hypertension · 2021Article
- Influence of coping strategies on the efficacy of YAM (Youth Aware of Mental Health): a universal school-based suicide preventive program.European child & adolescent psychiatry · 2020Article
- Psychopathology is associated with reproductive health risk in European adolescents.Reproductive health · 2018Article
- Interactions between youth and mental health professionals: The Youth Aware of Mental health (YAM) program experience.PloS one · 2018Article
- Correlates of sexual initiation among European adolescents.PloS one · 2018Article
- Assigning Clinical Significance and Symptom Severity Using the Zung Scales: Levels of Misclassification Arising from Confusion between Index and Raw Scores.Depression research and treatment · 2018Article
- Factors associated with different smoking status in European adolescents: results of the SEYLE study.European child & adolescent psychiatry · 2017Article
- Mental health difficulties and suicidal behaviours among young migrants: multicentre study of European adolescents.BJPsych open · 2017Article
- Prospective risk for suicidal thoughts and behaviour in adolescents with onset, maintenance or cessation of direct self-injurious behaviour.European child & adolescent psychiatry · 2017Article
- A Theater Intervention to Promote Communication and Disclosure of Suicidal Ideation.Journal of applied communication research : JACR · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 19 institutions in 14 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMental health problems and risk behaviours among young people are of great public health concern. Consequently, within the VII Framework Programme, the European Commission funded the Saving and Empowering Young Lives in Europe (SEYLE) project. This Randomized Controlled Trial (RCT) was conducted in eleven European countries, with Sweden as the coordinating centre, and was designed to identify an effective way to promote mental health and reduce suicidality and risk taking behaviours among adolescents.
objectiveTo describe the methodological and field procedures in the SEYLE RCT among adolescents, as well as to present the main characteristics of the recruited sample.
methodsAnalyses were conducted to determine: 1) representativeness of study sites compared to respective national data; 2) response rate of schools and pupils, drop-out rates from baseline to 3 and 12 month follow-up, 3) comparability of samples among the four Intervention Arms; 4) properties of the standard scales employed: Beck Depression Inventory, Second Edition (BDI-II), Zung Self-Rating Anxiety Scale (Z-SAS), Strengths and Difficulties Questionnaire (SDQ), World Health Organization Well-Being Scale (WHO-5).
resultsParticipants at baseline comprised 12,395 adolescents (M/F: 5,529/6,799; mean age=14.9±0.9) from Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain. At the 3 and 12 months follow up, participation rates were 87.3% and 79.4%, respectively. Demographic characteristics of participating sites were found to be reasonably representative of their respective national population. Overall response rate of schools was 67.8%. All scales utilised in the study had good to very good internal reliability, as measured by Cronbach's alpha (BDI-II: 0.864; Z-SAS: 0.805; SDQ: 0.740; WHO-5: 0.799).
conclusionsSEYLE achieved its objective of recruiting a large representative sample of adolescents within participating European countries. Analysis of SEYLE data will shed light on the effectiveness of important interventions aimed at improving adolescent mental health and well-being, reducing risk-taking and self-destructive behaviour and preventing suicidality.
trial registrationUS National Institute of Health (NIH) clinical trial registry (NCT00906620) and the German Clinical Trials Register (DRKS00000214).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.