ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2013
Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Mouse Model of Sutured Endothelial Keratoplasty Technique.Journal of clinical medicine · 2025Article
- Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.Materials today. Bio · 2025Article
- Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring.Frontiers in immunology · 2025Article
- Review
- Redefining the human corneal immune compartment using dynamic intravital imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology.Experimental eye research · 2021Review
- Parallel Multi-Omics in High-Risk Subjects for the Identification of Integrated Biomarker Signatures of Type 1 Diabetes.Biomolecules · 2021Article
- Corneal Allografts: Factors for and against Acceptance.Journal of immunology research · 2021Review
- Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation.Journal of innate immunity · 2021Article
- Understanding Immune Responses to Surgical Transplant Procedures in Stevens Johnsons Syndrome Patients.Frontiers in medicine · 2021Article
- Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.Cellular and molecular life sciences : CMLS · 2018Review
- Inhibition of lymphangiogenesis in vitro and in vivo by the multikinase inhibitor nintedanib.Drug design, development and therapy · 2017Article
- Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection.Mediators of inflammation · 2017Review
- High-Risk Corneal Graft Rejection in the Setting of Previous Corneal Herpes Simplex Virus (HSV)-1 Infection.Investigative ophthalmology & visual science · 2016Article
- Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice.Bio-protocol · 2015Article
- Recruitment of Donor T Cells to the Eyes During Ocular GVHD in Recipients of MHC-Matched Allogeneic Hematopoietic Stem Cell Transplants.Investigative ophthalmology & visual science · 2015Article
- In vivo downregulation of innate and adaptive immune responses in corneal allograft rejection by HC-HA/PTX3 complex purified from amniotic membrane.Investigative ophthalmology & visual science · 2014Article
- The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success.Immunologic research · 2013Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
Keratoplasty is the primary treatment to cure blindness due to corneal opacification. However, immune-mediated rejection remains the leading cause of keratoplasty failure. Here, we utilize an in vivo imaging approach to monitor, track, and characterize in real-time the recruitment of GFP-labeled allo-specific activated (Bonzo) T cells during corneal allograft rejection. We show that the recruitment of effector T cells to the site of transplantation determined the fate of corneal allografts, and that local intra-graft production of CCL5 and CXCL9/10 regulated motility patterns of effector T cells in situ, and correlated with allograft rejection. We also show that different motility patterns associate with distinct in vivo phenotypes (round, elongated, and ruffled) of graft-infiltrating effector T cells with varying proportions during progression of rejection. The ruffled phenotype was characteristic of activated effectors T cells and predominated during ongoing rejection, which associated with significantly increased T cell dynamics within the allografts. Importantly, CCR5/CXCR3 blockade decreased the motility, size, and number of infiltrating T cells and significantly prolonged allograft survival. Our findings indicate that chemokines produced locally within corneal allografts play an important role in the in situ activation and dynamic behavior of infiltrating effector T cells, and may guide targeted interventions to promote graft survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.