ArticleBMC infectious diseases2013
Longitudinal genetic analyses of Staphylococcus aureus nasal carriage dynamics in a diverse population.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The typhoid Mary legacy: Genomic epidemiology uncovers contemporary carriage dynamics across two decades of enteric fever surveillance in England and Wales.PLoS neglected tropical diseases · 2026Article
- Nasal microbiome inhabitants with anti-Microbiology spectrum · 2025Article
- Zoonotic transmission of asymptomatic carriageMicrobial genomics · 2024Article
- The intra-host evolutionary landscape and pathoadaptation of persistentMicrobial genomics · 2023Article
- Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization.PLoS computational biology · 2023Article
- Article
- Nasal microbiome disruption and recovery after mupirocin treatment in Staphylococcus aureus carriers and noncarriers.Scientific reports · 2022Article
- Phylodynamic signatures in the emergence of community-associated MRSA.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection.BMC infectious diseases · 2022Article
- Methicillin-resistantFuture science OA · 2022Article
- Ecology and Genetic Lineages of NasalPathogens (Basel, Switzerland) · 2021Review
- Article
- The SrrAB two-component system regulatesProceedings of the National Academy of Sciences of the United States of America · 2020Article
- IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue.Mucosal immunology · 2020Article
- Patterns and Predictors ofJournal of clinical microbiology · 2019Article
- Colonization of HIV-Infected Children with Methicillin-ResistantPathogens (Basel, Switzerland) · 2019Article
- Longitudinal Population Dynamics ofFrontiers in genetics · 2019Article
- Face Mask Use and Persistence of Livestock-associatedEnvironmental health perspectives · 2018Article
- Evaluation of the Pig-Tailed Macaque (Macaca nemestrina) as a Model of Human Staphylococcus aureus Nasal Carriage.Infection and immunity · 2018Article
- Cessation from Smoking Improves Innate Host Defense and Clearance of Experimentally Inoculated Nasal Staphylococcus aureus.Infection and immunity · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundStaphylococcus aureus (SA) nasal colonization plays a critical role in the pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be effective in reducing endogenous infections. To understand SA nasal colonization and its relation with consequent disease, assessment of nasal carriage dynamics and genotypic diversity among a diverse population is a necessity.
resultsWe have performed extensive longitudinal monitoring of SA nasal carriage isolates in 109 healthy individuals over a period of up to three years. Longitudinal sampling revealed that 24% of the individuals were persistent SA nasal carriers while 32% were intermittent. To assess the genetic relatedness between different SA isolates within our cohort, multi locus sequence typing (MLST) was performed. MLST revealed that not only were strains colonizing intermittent and persistent nasal carriers genetically similar, belonging to the same clonal complexes, but strain changes within the same host were also observed over time for both types of carriers. More highly discriminating genetic analyses using the hypervariable regions of staphylococcal protein A and clumping factor B virulence genes revealed no preferential colonization of specific SA strains in persistent or intermittent carriers. Moreover, we observed that a subset of persistent and intermittent carriers retained clinically relevant community-acquired methicillin-resistant SA (CA-MRSA) strains in their nares over time.
conclusionsThe findings of this study provides added perspective on the nasal carriage dynamics between strains colonizing persistent and intermittent carriers; an area currently in need of assessment given that persistent carriers are at greater risk of autoinfection than intermittent carriers.
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