Evidence map›Paper›PMID 23678950›Full record

ArticleMolecular microbiology2013

A novel RNA polymerase-binding protein controlling genes involved in spore germination in Bacillus subtilis.

Bjorn A Traag, Arturo Ramirez-Peralta, Anna F Wang Erickson, Peter Setlow, Richard Losick

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. MclX modulates the process of mother cell lysis by SpoIIID inApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bjorn A TraagDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Arturo Ramirez-Peralta
Anna F Wang Erickson
Peter Setlow
Richard Losick
Harvard University · USUConn Health · US

Funding

Role of RNA Polymerase in Bacterial DifferentionR01GM018568 · NIGMS · HARVARD UNIVERSITY · PI LOSICK, RICHARD MARC · 1985 to 2018
$11.5M
ROLE OF RNA POLYMERASE IN BACTERIAL DIFFERENTIATIONR37GM018568 · NIGMS · HARVARD UNIVERSITY · PI LOSICK, RICHARD MARC · 1990 to 1999
–
NIGMS NIH HHS GM18568NIGMS NIH HHS R01 GM018568NIGMS NIH HHS R37 GM018568
6 · The paper itself

Abstract

A growing class of proteins regulates transcription through interaction with DNA-dependent RNA polymerase. Here we report that a recently identified, highly conserved sporulation gene ylyA encodes a novel RNA polymerase-binding protein that influences the expression of genes under the control of the late-acting, sporulation sigma factor σ(G) in Bacillus subtilis. Spores from a ylyA mutant exhibited defects in germination corresponding to changes in the levels of membrane receptors for spore germinants and a protein channel governing the release of dipicolinic acid and hydration of the spore core during germination. Purified YlyA interacted with RNA polymerase and stimulated transcription from promoters dependent on σ(G) but not promoters dependent on the housekeeping sigma factor σ(A) . YlyA is a previously unrecognized RNA polymerase-binding protein that is dedicated to modulating the expression of genes involved in spore germination.

Indexed as

Gene Expression Regulation, BacterialBacillus subtilisBacterial ProteinsDNA-Directed RNA PolymerasesGene Knockout TechniquesProtein BindingSigma FactorSpores, BacterialBacterial ProteinsDNA-Directed RNA PolymerasesSigma Factor

Identifiers

PMID23678950
PMCPMC3694343
OpenAlexW2120574981

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.