ArticleJournal of Korean medical science2013
Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain.
Article in Journal of Korean medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A new therapeutic strategy for spotted fever group rickettsioses: a proposal for evaluating combination therapy with tetracycline and fluoroquinolones.Frontiers in cellular and infection microbiology · 2026Article
- Scrub Typhus and the Misconception of Doxycycline Resistance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Causes of acute undifferentiated fever and the utility of biomarkers in Chiangrai, northern Thailand.PLoS neglected tropical diseases · 2018Observational
- Antimicrobial Resistance inMicrobiology spectrum · 2018Article
- Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin.Korean journal of pediatrics · 2017Article
- Tsutsugamushi disease presenting with aortic valve endocarditis: a case report and literature review.American journal of cardiovascular disease · 2016Article
- Severe scrub typhus infection: Clinical features, diagnostic challenges and management.World journal of critical care medicine · 2015Review
- In vitro Antagonism between Cefotaxime and Anti-Rickettsial Antibiotics against Orientia tsutsugamushi.Infection & chemotherapy · 2014Article
- In vitro bacteriostatic effects of rifampin on Orientia tsutsugamushi.Journal of Korean medical science · 2014Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of quinolone for treatment of rickettsial diseases remains controversial. Recent clinical studies suggest that quinolone is not as effective as others in patients with rickettsial diseases including scrub typhus, although the mechanism is not well understood. In this study, we evaluated the mutation in gyrA associated with quinolone resistance. We prospectively enrolled scrub typhus patients, collected blood samples and clinical data from October, 2010 to November, 2011. Among the 21 patients enrolled, one initially received ciprofloxacin for 3 days but was switched to doxycycline due to clinical deterioration. We obtained the gyrA gene of Orientia tsutsugamushi from 21 samples (20 Boryong strain, 1 Kato strain) and sequenced the quinolone resistance-determining region. All of 21 samples had the Ser83Leu mutation in the gyrA gene, which is known to be associated with quinolone resistance. This suggests that quinolones may be avoided for the treatment of serious scrub typhus.
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