ArticleJournal of virology2013
Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo.bioRxiv : the preprint server for biology · 2026Article
- Virus infection and vesicle trafficking.Frontiers in immunology · 2025Review
- Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response.Frontiers in immunology · 2025Article
- Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation.Science advances · 2023Article
- Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity.Frontiers in aging neuroscience · 2023Article
- Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species.International journal of molecular sciences · 2021Review
- Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach.Vaccines · 2021Article
- Polymorphisms of HLA-B: influences on assembly and immunity.Current opinion in immunology · 2020Review
- The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α.Frontiers in cellular and infection microbiology · 2020Article
- Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer.Ecancermedicalscience · 2019Article
- Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.Cell host & microbe · 2018Article
- Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity.eLife · 2018Article
- Article
- BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.Cancer immunology research · 2015Article
- Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.Frontiers in immunology · 2015Review
- Article
- Direct interrogation of viral peptides presented by the class I HLA of HIV-infected T cells.Journal of virology · 2014Article
- HIV-1 accessory proteins adapt cellular adaptors to facilitate immune evasion.PLoS pathogens · 2014Review
- Genomic architecture of HIV-1 infection: current status & challenges.The Indian journal of medical research · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Certain antigen-presenting cells (APCs) process and present extracellular antigen with major histocompatibility complex class I (MHC-I) molecules to activate naive CD8(+) T cells in a process termed cross-presentation. We used insights gained from HIV immune evasion strategies to demonstrate that the clathrin adaptor protein adaptor protein 1 (AP-1) is necessary for cross-presentation by MHC-I molecules containing a cytoplasmic tail tyrosine signal (murine MHC-I molecules, human MHC-I HLA-A and HLA-B allotypes). In contrast, AP-1 activity was not needed for cross-presentation by MHC-I molecules containing a human MHC-I HLA-C cytoplasmic tail, which does not contain a tyrosine signal. AP-1 activity was also dispensable for presentation of endogenous antigens by MHC-I via the classical pathway. In APCs, we show that HIV Nef disrupts cross-presentation by MHC-I containing the tyrosine signal but does not affect cross-presentation by MHC-I containing the HLA-C cytoplasmic tail. Thus, we provide evidence for two separable cross-presentation pathways, only one of which is targeted by HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.