ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Most vesicles in a central nerve terminal participate in recycling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- From Synaptic Physiology to Synaptic Pathology: The Enigma of α-Synuclein.International journal of molecular sciences · 2024Review
- Article
- Spike Activity Regulates Vesicle Filling at a Glutamatergic Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models.Behavioral neuroscience · 2018Article
- Synaptic Vesicle Endocytosis in Different Model Systems.Frontiers in cellular neuroscience · 2018Review
- Synaptic vesicle pool-specific modification of neurotransmitter release by intravesicular free radical generation.The Journal of physiology · 2017Article
- Impact of vesicular glutamate leakage on synaptic transmission at the calyx of Held.The Journal of physiology · 2017Article
- Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-Neurochemical research · 2017Article
- Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.The Journal of clinical investigation · 2016Article
- The calyx of Held in the auditory system: Structure, function, and development.Hearing research · 2016Review
- Quantitative analysis of vesicle recycling at the calyx of Held synapse.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A three-pool model dissecting readily releasable pool replenishment at the calyx of held.Scientific reports · 2015Article
- Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held.The Journal of physiology · 2014Article
- Synaptic vesicle recycling: steps and principles.The EMBO journal · 2014Review
- Myosin light chain kinase accelerates vesicle endocytosis at the calyx of Held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Visualizing presynaptic function.Nature neuroscience · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Studies over the last decade using FM dyes to label vesicles at many terminals, including the calyx-type nerve terminal, led to a well accepted "principle" that only a small fraction of vesicles (∼5-20%) participate in recycling under physiological conditions. This principle imposes a large challenge in maintaining synaptic transmission during repetitive firing, because the small recycling pool may limit the number of available vesicles for release and nerve terminals would have to distinguish the recycling pool from the reserve pool and keep reserve pool vesicles from being used. By recording the presynaptic capacitance changes and the postsynaptic EPSC at rat calyx of Held synapses in the absence or presence of transmitter glutamate in nerve terminals, we developed a new method to count functional recycling vesicles. We found that essentially all vesicles in calyces participated in recycling, challenging the small-recycling-pool principle established by FM dye labeling. Nerve terminals may use all available vesicles to maximize their ability in maintaining synaptic transmission during repetitive firing.
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Registered trials
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