ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Nucleus accumbens activity dissociates different forms of salience: evidence from human intracranial recordings.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Attentional Modulation of Brain Responses to Primary Appetitive and Aversive Stimuli.PloS one · 2015Trial
- Sildenafil promotes dual memory effects in young rats: involvement of dopamine reuptake.Psychopharmacology · 2025Article
- Structural and functional correlates of olfactory reward processing in behavioral variant frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Nucleus accumbens local circuit for cue-dependent aversive learning.Cell reports · 2023Article
- Cognitive and neural bases of visual-context-guided decision-making.NeuroImage · 2023Article
- Attention and schema violations of real world scenes differentially modulate time perception.Scientific reports · 2023Article
- Reward learning and working memory: Effects of massed versus spaced training and post-learning delay period.Memory & cognition · 2022Article
- Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.Molecular psychiatry · 2021Article
- Modeling nucleus accumbens : A Computational Model from Single Cell to Circuit Level.Journal of computational neuroscience · 2021Article
- Automatic Sensory Predictions: A Review of Predictive Mechanisms in the Brain and Their Link to Conscious Processing.Frontiers in human neuroscience · 2021Review
- The gains of a 4-week cognitive training are not modulated by novelty.Human brain mapping · 2020Article
- The ventral striatum dissociates information expectation, reward anticipation, and reward receipt.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors.Genes, brain, and behavior · 2019Article
- A Comparison of Auditory Oddball Responses in Dorsolateral Prefrontal Cortex, Basolateral Amygdala, and Auditory Cortex of Macaque.Journal of cognitive neuroscience · 2019Article
- Novelty Before or After Word Learning Does Not Affect Subsequent Memory Performance.Frontiers in psychology · 2019Article
- Contributions of the Ventral Striatum to Conscious Perception: An Intracranial EEG Study of the Attentional Blink.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest.Frontiers in human neuroscience · 2017Article
- Functional states of rat cortical circuits during the unpredictable availability of a reward-related cue.Scientific reports · 2016Article
- Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens.Journal of neurophysiology · 2016Article
- Combining electroencephalographic activity and instantaneous heart rate for assessing brain-heart dynamics during visual emotional elicitation in healthy subjects.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theoretical models and empirical work indicate a critical role of the NAcc in salience processing. For instance, the NAcc not only responds to appetitive and aversive information, but it also signals novelty, contextual deviance, and action monitoring. However, because most studies have investigated only one specific type of salience independently, it remains unclear how the NAcc concurrently differentiates between different forms of salience. To investigate this issue, we used intracranial electroencephalography in human epilepsy patients together with a previously established visual oddball paradigm. Here, three different oddball categories (novel, neutral, and target images) were infrequently presented among a standard scene image, and subjects responded to the target via button press. This task allowed us to differentiate "item novelty" (new vs neutral oddballs) from "contextual deviance" (neutral oddballs vs standard images) and "targetness" (target vs neutral oddballs). Time-frequency analysis revealed a dissociation between item novelty and contextual deviance on the basis of decreases in either θ (4-8 Hz) or β power (20-30 Hz). Targetness, on the other hand, was signaled by positive deflections in the stimulus-locked local field potentials, which, importantly, correlated with subjects' reaction times. These findings indicate that, in an ongoing stream of information, the NAcc differentiates between types of salience by distinct neural mechanisms to guide goal-directed behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.