ArticleThe Journal of experimental biology2013
Activity-dependent gene expression in honey bee mushroom bodies in response to orientation flight.
Article in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic variation influences food-sharing sociability in honey bees.PLoS biology · 2025Article
- Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees.Nature communications · 2025Article
- Integrating computer vision and molecular neurobiology to bridge the gap between behavior and the brain.Current opinion in insect science · 2024Review
- Tropical and montane Apis cerana show distinct dance-distance calibration curves.The Journal of experimental biology · 2024Article
- Investigating boundary-geometry use by whip spiders (Phrynus marginemaculatus) during goal-directed navigation.Learning & behavior · 2024Article
- Gut microbiota contribute to variations in honey bee foraging intensity.The ISME journal · 2024Article
- Transcriptomic responses to location learning by honeybee dancers are partly mirrored in the brains of dance-followers.Proceedings. Biological sciences · 2023Article
- Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control.Molecular and cellular neurosciences · 2023Article
- Cell assembly analysis of neural circuits for innate behavior inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary dynamics of mushroom body Kenyon cell types in hymenopteran brains from multifunctional type to functionally specialized types.Science advances · 2023Article
- Context-dependent influence of threat on honey bee social network dynamics and brain gene expression.The Journal of experimental biology · 2022Article
- Visual learning in a virtual reality environment upregulates immediate early gene expression in the mushroom bodies of honey bees.Communications biology · 2022Article
- Landmark navigation in a mantis shrimp.Proceedings. Biological sciences · 2020Article
- Neural activity mapping of bumble bee (Bombus ignitus) brains during foraging flight using immediate early genes.Scientific reports · 2020Article
- Review
- A Novel Thermal-Visual Place Learning Paradigm for Honeybees (Frontiers in behavioral neuroscience · 2020Article
- Immediate early gene kakusei potentially plays a role in the daily foraging of honey bees.PloS one · 2020Article
- Valence of social information is encoded in different subpopulations of mushroom body Kenyon cells in the honeybee brain.Proceedings. Biological sciences · 2019Article
- Honey bee (Apis mellifera) larval pheromones may regulate gene expression related to foraging task specialization.BMC genomics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The natural history of adult worker honey bees (Apis mellifera) provides an opportunity to study the molecular basis of learning in an ecological context. Foragers must learn to navigate between the hive and floral locations that may be up to miles away. Young pre-foragers prepare for this task by performing orientation flights near the hive, during which they begin to learn navigational cues such as the appearance of the hive, the position of landmarks, and the movement of the sun. Despite well-described spatial learning and navigation behavior, there is currently limited information on the neural basis of insect spatial learning. We found that Egr, an insect homolog of Egr-1, is rapidly and transiently upregulated in the mushroom bodies in response to orientation. This result is the first example of an Egr-1 homolog acting as a learning-related immediate-early gene in an insect and also demonstrates that honey bee orientation uses a molecular mechanism that is known to be involved in many other forms of learning. This transcriptional response occurred both in naïve bees and in foragers induced to re-orient. Further experiments suggest that visual environmental novelty, rather than exercise or memorization of specific visual cues, acts as the stimulus for Egr upregulation. Our results implicate the mushroom bodies in spatial learning and emphasize the deep conservation of Egr-related pathways in experience-dependent plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.