ArticleAmerican journal of physiology. Renal physiology2013
Early life stress sensitizes the renal and systemic sympathetic system in rats.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Maternal Separation and Negative Renal Programming, Evidence of Morphofunctional Alterations in Rodent Models: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings With Human Correlation.Gastroenterology · 2026Article
- Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension.Experimental physiology · 2026Article
- Localizing somatic symptoms associated with childhood maltreatment.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress.Hypertension (Dallas, Tex. : 1979) · 2021Article
- A Scoping Review of Life-Course Psychosocial Stress and Kidney Function.Children (Basel, Switzerland) · 2021Article
- Maternal separation-induced increases in vascular stiffness are independent of circulating angiotensinogen levels.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Intrarenal Renin Angiotensin System Imbalance During Postnatal Life Is Associated With Increased Microvascular Density in the Mature Kidney.Frontiers in physiology · 2020Article
- Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension.Frontiers in neuroscience · 2020Review
- Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and CystathionineOxidative medicine and cellular longevity · 2020Article
- Female Mice Exposed to Postnatal Neglect Display Angiotensin II-Dependent Obesity-Induced Hypertension.Journal of the American Heart Association · 2019Article
- Childhood adversity and mechanistic links to hypertension risk in adulthood.British journal of pharmacology · 2019Review
- Distinct effects of early-life experience and trait aggression on cardiovascular reactivity and recovery.Physiology & behavior · 2019Article
- Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.PloS one · 2019Article
- Maternal Deprivation Induces Memory Deficits That Are Reduced by One Aerobic Exercise Shot Performed after the Learning Session.Neural plasticity · 2019Article
- Early life stress induces immune priming in kidneys of adult male rats.American journal of physiology. Renal physiology · 2018Article
- Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1.Journal of the American Heart Association · 2018Article
- Maternal separation diminishes α-adrenergic receptor density and function in renal vasculature from male Wistar-Kyoto rats.American journal of physiology. Renal physiology · 2017Article
- Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents.Neuroscience and biobehavioral reviews · 2017Review
- Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats.Neurotoxicity research · 2017Article
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4 authors at 2 institutions in 1 country.
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Abstract
We hypothesized that maternal separation (MS), an early life stress model, induces a sensitization of the sympathetic system. To test this hypothesis, we evaluated the renal and systemic sympathetic system in 12- to 14-wk-old male control or MS rats with the following parameters: 1) effect of renal denervation on conscious renal filtration capacity, 2) norepinephrine (NE) content in key organs involved in blood pressure control, and 3) acute systemic pressor responses to adrenergic stimulation or ganglion blockade. MS was performed by separating pups from their mothers for 3 h/day from day 2 to 14; controls were nonhandled littermates. Glomerular filtration rate (GFR) was examined in renal denervated (DnX; within 2 wk) or sham rats using I¹²⁵-iothalamate plasma clearance. MS-DnX rats showed significantly increased GFR compared with MS-SHAM rats (3.8 ± 0.4 vs. 2.4 ± 0.2 ml/min, respectively, P < 0.05), whereas DnX had no effect in controls, indicating that renal nerves regulate GFR in MS rats. NE content was significantly increased in organ tissues from MS rats (P < 0.05, n = 6-8), suggesting a sensitization of the renal and systemic sympathetic system. Conscious MS rats displayed a significantly greater increase in mean arterial pressure (MAP) in response to NE (2 μg/kg ip) and a greater reduction in MAP in response to mecamylamine (2 mg/kg ip, P < 0.05, n = 4) monitored by telemetry, indicating that MS rats exhibit exaggerated responses to sympathetic stimulation. In conclusion, these data indicate that MS sensitizes the renal and systemic sympathetic system ultimately impairing blood pressure regulation.
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