ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- The median preoptic nucleus is a key site for estradiol regulation of sleep-wake behaviors in females rats.Sleep · 2026Article
- Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Median Preoptic Nucleus is a Key Site for Estradiol Regulation of Sleep-Wake Behaviors in Females Rats.bioRxiv : the preprint server for biology · 2025Article
- Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring.Biology of sex differences · 2025Article
- Ovarian Suppression: Early Menopause, Late Effects.Current oncology reports · 2024Review
- Reproductive hormones and sex chromosomes drive sex differences in the sleep-wake cycle.Frontiers in neuroscience · 2024Review
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior.Frontiers in neuroscience · 2024Review
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- The Influence of Steroid Hormones on Tooth Wear in Children and in Adolescents.Journal of clinical medicine · 2022Article
- Estradiol influences adenosinergic signaling and nonrapid eye movement sleep need in adult female rats.Sleep · 2022Article
- Differences in Polysomnography Parameters of Women in the Post and Transitional Phases of Menopause.Cureus · 2021Article
- Relationship between hormonal contraceptives and sleep among women of reproductive age: a systematic review protocol.BMJ open · 2021Article
- Chronic modafinil therapy ameliorates depressive-like behavior, spatial memory and hippocampal plasticity impairments, and sleep-wake changes in a surgical mouse model of menopause.Translational psychiatry · 2021Article
- The Role of Reproductive Hormones in Sex Differences in Sleep Homeostasis and Arousal Response in Mice.Frontiers in neuroscience · 2021Article
- Role of Ovarian Hormones in the Modulation of Sleep in Females Across the Adult Lifespan.Endocrinology · 2020Review
- Sex- and Age-dependent Differences in Sleep-wake Characteristics of Fisher-344 Rats.Neuroscience · 2020Article
- Neurobiological and Hormonal Mechanisms Regulating Women's Sleep.Frontiers in neuroscience · 2020Review
- Analysis of the long-term beneficial effects of menopausal hormone therapy on sleep quality and menopausal symptoms.Experimental and therapeutic medicine · 2019Article
- Decreased serum potassium may disturb sleep homeostasis in essential hypertensives.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ovarian hormones are thought to modulate sleep and fluctuations in the hormonal milieu are coincident with sleep complaints in women. In female rats, estradiol increases waking and suppresses sleep. In this study, we asked whether this effect is mediated via circadian or homeostatic regulatory mechanisms. Ovariectomized female rats received daily injections of estradiol benzoate (EB) or sesame oil that mimicked the rapid increase and subsequent decline of circulating estradiol at proestrus. In one experiment, animals were sleep deprived for 6 h starting at lights-on, so that recovery began in the mid-light phase; in the second experiment, animals were sleep deprived starting in the mid-light phase, so that recovery began at lights-off. EB suppressed baseline rapid eye movement (REM) and non-REM (NREM) sleep and increased waking in the dark phase. In both experiments, EB enhanced REM recovery in the light phase while suppressing it in the dark compared with oil; this effect was most pronounced in the first 6 h of recovery. By contrast, NREM recovery was largely unaffected by EB. In summary, EB enhanced waking and suppressed sleep, particularly REM sleep, in the dark under baseline and recovery conditions. These strong temporally dependent effects suggest that EB consolidates circadian sleep-wake rhythms in female rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.