Evidence map›Paper›PMID 23677749›Full record

Trial reportJournal of neuro-oncology2013

Cognitive rehabilitation for early post-surgery inpatients affected by primary brain tumor: a randomized, controlled trial.

Chiara Zucchella, Annarita Capone, Valentina Codella, Alessandro Marco De Nunzio, Carmine Vecchione, Giorgio Sandrini, Andrea Pace, Francesco Pierelli, Michelangelo Bartolo

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 8 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 8 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
  6. Pooled it
  7. Multidisciplinary rehabilitation after primary brain tumour treatment.The Cochrane database of systematic reviews · 2015
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Rehabilitation in patients with primary brain tumors: a scoping review of current guideline recommendations.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  13. Article
  14. Article
  15. Remote group intervention for adults with cancer-related cognitive impairment: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  16. Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  17. Review
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Chiara ZucchellaNeurorehabilitation Unit, IRCCS Neurological Mediterranean Institute NEUROMED, Via Atinense 18, 86077, Pozzilli, Isernia, Italy.
Annarita Capone
Valentina Codella
Alessandro Marco De Nunzio
Carmine Vecchione
Giorgio Sandrini
Andrea Pace
Francesco Pierelli
Michelangelo Bartolo
Istituto Neurologico Mediterraneo · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · ITSapienza University of Rome · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment is one of the most common neurological disorders in neuro-oncological patients and exerts a deep negative impact on quality of life interfering with familiar, social and career-related activities. To test the effectiveness of early cognitive rehabilitation treatment for inpatients affected by primary brain tumors. Out of 109 consecutive patients enrolled in the study, 58 patients were randomly assigned to a rehabilitation group or to a control group. The rehabilitation consisted of 16 one-hour individual sessions of therapist-guided cognitive training, spread over 4 weeks, combining computer exercises and metacognitive training. Patients in the control group received usual care without cognitive training. All patients were evaluated by means of a comprehensive neuropsychological battery at the admission (T0) and after 4 weeks (T1). Patients in the rehabilitation group showed a significant improvement of cognitive functions. In particular, the domains that benefited most from the training were visual attention and verbal memory. The control group exhibited only a slightly, not statistically relevant, enhancement of cognitive performances. Cognitive rehabilitation for neuro-oncological inpatients resulted in a significant enhancement of cognitive performances after the training, also providing a foundation for early administration. Future research should be aimed to clarify the patients' characteristics that predict neuropsychological improvement, to identify the most effective elements in rehabilitative programs and to study the effects of treatment extension to everyday life.

Indexed as

AdultAgedAttentionBrain NeoplasmsCognition DisordersCognitive Behavioral TherapyExercise TherapyFemaleHumansInpatientsMaleMental Status ScheduleMiddle AgedNeuropsychological TestsRecognition, PsychologyStatistics, Nonparametric

Identifiers

PMID23677749
OpenAlexW2015313936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.