Evidence map›Paper›PMID 23677651›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2013

Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting.

Savas Tasoglu, Hooman Safaee, Xiaohui Zhang, James L Kingsley, Paolo N Catalano, Umut Atakan Gurkan, Aida Nureddin, Emre Kayaalp, Raymond M Anchan, Richard L Maas and 2 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355937 naunknown statusnot on this mapstarted 2018, after this paper: background citation

The Effects of Using Microfluidic Separation Sperm Selection for Unexplained Infertility(UEI) and Reccurrent Implantation Failure(RIF)

TypeinterventionalSponsorAcibadem UniversityRan2018 to 2019Enrolled200ConditionsUnexplained Infertility, Recurrent Implantation FailureArmsSperm Chip
NCT03960229 nacompletednot on this mapstarted 2019, after this paper: background citation

The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor: a Randomized Controlled Trial

TypeinterventionalSponsorBezmialem Vakif UniversityRan2019 to 2019Enrolled139ConditionsMale Infertility, Infertility, MaleArmsMicroFluidic Sperm Sorting Chips, Gradient-Density Centrifugation
3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Trial
  2. Article
  3. Sperm Preparation in ART: Traditional Methods and Emerging Technologies.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Savas TasogluBio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hooman Safaee
Xiaohui Zhang
James L Kingsley
Paolo N Catalano
Umut Atakan Gurkan
Aida Nureddin
Emre Kayaalp
Raymond M Anchan
Richard L Maas
Erkan Tüzel
Utkan Demirci

Funding

SysCODE: Tooth Germ Design and Engineering (2 of 10)RL1DE019021 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI MAAS, RICHARD L · 2007 to 2011
$2.8M
Point-of-Care Rapid Blood Testing Using Microfluidic DevicesR01AI081534 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2009 to 2013
$2.1M
Minimizing the role of cryoprotectant toxicity for cryopreservationR01EB015776 · NIBIB · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN · 2012 to 2015
$1.5M
Antibody-based cell purification at resource limited setting for HIVR21AI087107 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2010 to 2011
$488k
Droplet Based Microfluidic Chip for CryopreservationR21EB007707 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMIRCI, UTKAN · 2008 to 2009
$478k
NIAID NIH HHS R01 AI081534NIAID NIH HHS R21 AI087107NIBIB NIH HHS R01 EB015776NIBIB NIH HHS R01 EB015776-01A1NIBIB NIH HHS R21 EB007707NIDCR NIH HHS 1RL1 DE019021NIDCR NIH HHS RL1 DE019021PHS HHS R01 A1081534
6 · The paper itself

Abstract

Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm.

Indexed as

Cell MovementAnimalsCell SeparationComputer SimulationHumansMaleMiceMicrofluidicsSpermatozoaTime Factorsbiodesignfertilitymicrofluidic sortingsperm exhaustionsperm sorting

Identifiers

PMID23677651
PMCPMC3821799

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.