ArticleNucleic acids research2013
WebScipio: Reconstructing alternative splice variants of eukaryotic proteins.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica.Current biology : CB · 2018Article
- The landscape of human mutually exclusive splicing.Molecular systems biology · 2017Article
- Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era.BMC evolutionary biology · 2017Article
- Fine-Tuning Motile Cilia and Flagella: Evolution of the Dynein Motor Proteins from Plants to Humans at High Resolution.Molecular biology and evolution · 2016Article
- Axonopathy in the Central Nervous System Is the Hallmark of Mice with a Novel Intragenic Null Mutation of Dystonin.Genetics · 2016Article
- Polyphyly of nuclear lamin genes indicates an early eukaryotic origin of the metazoan-type intermediate filament proteins.Scientific reports · 2015Article
- diArk--the database for eukaryotic genome and transcriptome assemblies in 2014.Nucleic acids research · 2015Article
- Six subgroups and extensive recent duplications characterize the evolution of the eukaryotic tubulin protein family.Genome biology and evolution · 2014Article
- Kassiopeia: a database and web application for the analysis of mutually exclusive exomes of eukaryotes.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate exon-intron structures are essential prerequisites in genomics, proteomics and for many protein family and single gene studies. We originally developed Scipio and the corresponding web service WebScipio for the reconstruction of gene structures based on protein sequences and available genome assemblies. WebScipio also allows predicting mutually exclusive spliced exons and tandemly arrayed gene duplicates. The obtained gene structures are illustrated in graphical schemes and can be analysed down to the nucleotide level. The set of eukaryotic genomes available at the WebScipio server is updated on a daily basis. The current version of the web server provides access to ∼3400 genome assembly files of >1100 sequenced eukaryotic species. Here, we have also extended the functionality by adding a module with which expressed sequence tag (EST) and cDNA data can be mapped to the reconstructed gene structure for the identification of all types of alternative splice variants. WebScipio has a user-friendly web interface, and we believe that the improved web server will provide better service to biologists interested in the gene structure corresponding to their protein of interest, including all types of alternative splice forms and tandem gene duplicates. WebScipio is freely available at http://www.webscipio.org.
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