ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Siglecs in allergy and asthma.Molecular aspects of medicine · 2023Review
- Analysis of Tumor Glycosylation Characteristics and Implications for Immune Checkpoint Inhibitor's Efficacy for Breast Cancer.Frontiers in immunology · 2022Article
- Eosinophil and mast cell Siglecs: From biology to drug target.Journal of leukocyte biology · 2020Review
- Sialic acid-binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses.Cellular and molecular life sciences : CMLS · 2020Review
- Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression.Cancer metastasis reviews · 2018Review
- Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils.Journal of leukocyte biology · 2018Article
- Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice.Journal of leukocyte biology · 2018Article
- Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency.Glycobiology · 2018Article
- Glycobiology of Eosinophilic Inflammation: Contributions of Siglecs, Glycans, and Other Glycan-Binding Proteins.Frontiers in medicine · 2017Review
- Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions.The European respiratory journal · 2016Review
- "Siglec"ting the allergic response for therapeutic targeting.Glycobiology · 2016Review
- Glycobiology simplified: diverse roles of glycan recognition in inflammation.Journal of leukocyte biology · 2016Review
- Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.Current opinion in allergy and clinical immunology · 2016Review
- Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.The Journal of allergy and clinical immunology · 2015Article
- Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation.The Journal of allergy and clinical immunology · 2015Review
- Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis.PloS one · 2015Article
- Siglec-mediated regulation of immune cell function in disease.Nature reviews. Immunology · 2014Review
- Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.Nature immunology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Sialic acid-binding, Ig-like lectin (Siglec)-F is highly expressed on mouse eosinophils and plays an important role in regulating levels of eosinophilic lung inflammation. In this study we investigated the mechanism of constitutive and inducible Siglec-F ligand expression by lung airway epithelial cells and inflammatory cells in wild-type (WT) and genetically altered mice (ST3Gal-III heterozygotes, Fuc-TIV/VII double null, STAT6 null). Flow cytometry demonstrated that Siglec-F ligands are constitutively expressed in vitro and in vivo in selected lung cell types (epithelial cells, eosinophils, macrophages, and mast cells, but not CD4, CD8, or B cells) and are induced in response to divergent stimuli, including innate stimuli (TLR ligands, Alternaria), Th2 cytokines (IL-4, IL-13), and adaptive immune stimuli (OVA allergen). Furthermore, studies of deficient mice demonstrated the greater importance of the sialyltransferase ST3Gal-III compared with fucosyltransferases Fuc-TIV/VII in the synthesis of the constitutive and inducible Siglec-F ligands by lung epithelial and nonepithelial cells. In keeping with this, ST3Gal-III heterozygote mice (deficient in expression of Siglec-F ligands) also had significantly enhanced OVA-induced eosinophilic airway inflammation associated with reduced eosinophil apoptosis. Reduced eosinophil apoptosis in the lung of ST3Gal-III-deficient mice is likely mediated by reduced epithelial expression of Siglec-F ligands as WT eosinophils (which highly express Siglec-F) cultured with ST3Gal-III-deficient epithelial cells (which do not express Siglec-F ligand) showed reduced eosinophil apoptosis compared with WT eosinophils cultured with WT epithelial cells. Overall, these studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung.
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Registered trials
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