ArticlePlant molecular biology2013
Tomato FRUITFULL homologues act in fruit ripening via forming MADS-box transcription factor complexes with RIN.
Article in Plant molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 111 citations in OpenAlex.
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- CRY1-GAIP1 complex mediates blue light to hinder the repression of PIF5 on AGL5 to promote carotenoid biosynthesis in mango fruit.Plant biotechnology journal · 2025Article
- Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrative analysis of the methylome and transcriptome of tomato fruit (Horticulture research · 2024Article
- The YABBY Transcription Factor, SlYABBY2a, Positively Regulates Fruit Septum Development and Ripening in Tomatoes.International journal of molecular sciences · 2024Article
- Transcriptional regulation of tomato fruit ripening.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Genome-Wide Characterization and Phylogenetic and Stress Response Expression Analysis of the MADS-Box Gene Family in Litchi (International journal of molecular sciences · 2024Article
- Fruit Development in Sweet Cherry.Plants (Basel, Switzerland) · 2022Review
- GWAS and transcriptome analysis reveal MADS26 involved in seed germination ability in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Comparative metabolomic and transcriptomic analysis reveals a coexpression network of the carotenoid metabolism pathway in the panicle of Setaria italica.BMC plant biology · 2022Article
- FRUITFULL-like genes regulate flowering time and inflorescence architecture in tomato.The Plant cell · 2022Article
- The metabolic changes that effect fruit quality during tomato fruit ripening.Molecular horticulture · 2022Review
- SlBEL11 affects tomato carotenoid accumulation by regulatingFrontiers in nutrition · 2022Article
- Identification of Candidate Chromosome Region Related to Melon (Frontiers in plant science · 2022Article
- Novel Translational and Phosphorylation Modification Regulation Mechanisms of Tomato (International journal of molecular sciences · 2021Article
- Changes in Morphology, Metabolism and Composition of Cuticular Wax in Zucchini Fruit During Postharvest Cold Storage.Frontiers in plant science · 2021Article
- Semi-dominant effects of a novel ripening inhibitor (rin) locus allele on tomato fruit ripening.PloS one · 2021Article
- Ubiquitination of phytoene synthase 1 precursor modulates carotenoid biosynthesis in tomato.Communications biology · 2020Article
- A Tetratricopeptide Repeat Protein Regulates Carotenoid Biosynthesis and Chromoplast Development in Monkeyflowers (The Plant cell · 2020Article
- Allelic Mutations in thePlant physiology · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tomato MADS-box transcription factor RIN acts as a master regulator of fruit ripening. Here, we identified MADS-box proteins that interact with RIN; we also provide evidence that these proteins act in the regulation of fruit ripening. We conducted a yeast two-hybrid screen of a cDNA library from ripening fruit, for genes encoding proteins that bind to RIN. The screen identified two MADS-box genes, FUL1 and FUL2 (previously called TDR4 and SlMBP7), both of which have high sequence similarity to Arabidopsis FRUITFULL. Expression analyses revealed that the FUL1 mRNA and FUL1 protein accumulate in a ripening-specific manner in tomato fruits and FUL2 mRNA and protein accumulate at the pre-ripening stage and throughout ripening. Biochemical analyses confirmed that FUL1 and FUL2 form heterodimers with RIN; this interaction required the FUL1 and FUL2 C-terminal domains. Also, the heterodimers bind to a typical target DNA motif for MADS-box proteins. Chromatin immunoprecipitation assays revealed that FUL1 and FUL2 bind to genomic sites that were previously identified as RIN-target sites, such as the promoter regions of ACS2, ACS4 and RIN. These findings suggest that RIN forms complexes with FUL1 and FUL2 and these complexes regulate expression of ripening-related genes. In addition to the functional redundancy between FUL1 and FUL2, we also found they have potentially divergent roles in transcriptional regulation, including a difference in genomic target sites.
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