ArticleProceedings. Biological sciences2013
Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences for allele pool composition and mating.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Long read genome unravels MHC I genomic architecture, evolution, and diversity loss iniScience · 2025Article
- No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.Proceedings. Biological sciences · 2024Article
- Immunogenetic-pathogen networks shrink in Tome's spiny rat, a generalist rodent inhabiting disturbed landscapes.Communications biology · 2024Article
- Limited associations between MHC diversity and reproductive success in a bird species with biparental care.Ecology and evolution · 2024Article
- Bw4 ligand and direct T-cell receptor binding induced selection on HLA A and B alleles.Frontiers in immunology · 2023Article
- Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals.Scientific reports · 2022Article
- MHCtools - an R package for MHC high-throughput sequencing data: Genotyping, haplotype and supertype inference, and downstream genetic analyses in non-model organisms.Molecular ecology resources · 2022Article
- Contemporary selection on MHC genes in a free-living ruminant population.Ecology letters · 2022Article
- Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina.Tropical animal health and production · 2021Article
- Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate.PLoS pathogens · 2021Article
- Balancing selection, genetic drift, and human-mediated introgression interplay to shape MHC (functional) diversity in Mediterranean brown trout.Ecology and evolution · 2021Article
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- Adult survival in migratory caribou is negatively associated with MHC functional diversity.Heredity · 2020Article
- Sex-specific impact of inbreeding on pathogen load in the striped dolphin.Proceedings. Biological sciences · 2020Article
- HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.Molecular biology and evolution · 2020Article
- MHC structuring and divergent allele advantage in a urodele amphibian: a hierarchical multi-scale approach.Heredity · 2019Article
- Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.Ecology and evolution · 2019Article
- Divergent Allele Advantage Provides a Quantitative Model for Maintaining Alleles with a Wide Range of Intrinsic Merits.Genetics · 2019Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is still debated whether main individual fitness differences in natural populations can be attributed to genome-wide effects or to particular loci of outstanding functional importance such as the major histocompatibility complex (MHC). In a long-term monitoring project on Galápagos sea lions (Zalophus wollebaeki), we collected comprehensive fitness and mating data for a total of 506 individuals. Controlling for genome-wide inbreeding, we find strong associations between the MHC locus and nearly all fitness traits. The effect was mainly attributable to MHC sequence divergence and could be decomposed into contributions of own and maternal genotypes. In consequence, the population seems to have evolved a pool of highly divergent alleles conveying near-optimal MHC divergence even by random mating. Our results demonstrate that a single locus can significantly contribute to fitness in the wild and provide conclusive evidence for the 'divergent allele advantage' hypothesis, a special form of balancing selection with interesting evolutionary implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.