ArticleThe Journal of investigative dermatology2013
Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis.
Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Molecular signatures and signaling interactions of the hair follicle stem cell niche.The Journal of investigative dermatology · 2026Article
- Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases.Stem cell reviews and reports · 2025Review
- Effect of an Autotaxin Inhibitor, 2-(4-Chlorophenyl)-7-methyl-8-pentylimidazo[1,2-ACS pharmacology & translational science · 2024Article
- Matricellular proteins in cutaneous wound healing.Frontiers in cell and developmental biology · 2022Review
- Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling.International journal of molecular sciences · 2020Review
- An updated classification of hair follicle morphogenesis.Experimental dermatology · 2019Review
- Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.eLife · 2018Article
- An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo.Journal of biomedical research · 2016Review
- Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.Developmental cell · 2015Article
- Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation.Experimental dermatology · 2014Article
- Autotaxin: structure-function and signaling.Journal of lipid research · 2014Review
- Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation.Developmental biology · 2014Article
- Hair follicle signaling networks: a dermal papilla-centric approach.The Journal of investigative dermatology · 2013Article
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5 authors at 1 institution in 1 country.
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Abstract
Systematic ablation of previously identified dermal papilla (DP) signature genes in embryonic DP precursors will reveal their functional roles during hair follicle morphogenesis. In this study, we validate Enpp2/Autotaxin as one of the highest expressed signature genes in postnatal DP, and demonstrate specific expression of this lysophosphatidic acid (LPA)-generating enzyme in embryonic dermal condensates. We further identify dermal and epidermal expression of several LPA receptors, suggesting that LPA signaling could contribute to follicle morphogenesis in both mesenchymal and epithelial compartments. We then use the recently characterized Cre-expressing Tbx18 knock-in line to conditionally ablate Enpp2 in embryonic DP precursors. Despite efficient gene knockout in embryonic day 14.5 (E14.5) dermal condensates, morphogenesis proceeds regularly with normal numbers, lengths, and sizes of all hair follicle types, suggesting that Enpp2 is not required for hair follicle formation. To interrogate DP signature gene expression, we finally isolate control and Enpp2-null DP precursors and identify the expression and upregulation of LIPH, an alternative LPA-producing enzyme, suggesting that this gene could functionally compensate for the absence of Enpp2. We conclude that future coablation of both LPA-producing enzymes or of several LPA receptors may reveal the functional role of LPA signaling during hair follicle morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.