ArticleThe ISME journal2013
A design-constraint trade-off underpins the diversity in ecologically important traits in species Escherichia coli.
Article in The ISME journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Article
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- Bayesian analysis of longitudinal RB-TnSeq resolves the fitness seascape in fluctuating environments.bioRxiv : the preprint server for biology · 2026Article
- Rapid adaptation accelerates competitive suppression in a parasite community.The ISME journal · 2026Article
- Carbon regime structures functional trait trajectories during primary succession in microorganisms.The ISME journal · 2026Article
- Methods for studying microbial acid stress responses: from molecules to populations.FEMS microbiology reviews · 2024Review
- Grow now, pay later: When should a bacterium go into debt?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates.BMC microbiology · 2024Article
- Cultivating antimicrobial resistance: how intensive agriculture ploughs the way for antibiotic resistance.Microbiology (Reading, England) · 2023Review
- Density-dependent effects are the main determinants of variation in growth dynamics between closely related bacterial strains.PLoS computational biology · 2022Article
- A Broad Continuum of E. coli Traits in Nature Associated with the Trade-off Between Self-preservation and Nutritional Competence.Microbial ecology · 2022Article
- Adaptation and competition in deteriorating environments.Proceedings. Biological sciences · 2021Article
- Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.BMC biology · 2021Article
- Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR).Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Hidden paths to endless forms most wonderful: Complexity of bacterial motility shapes diversification of latent phenotypes.BMC evolutionary biology · 2020Article
- Article
- Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion.eLife · 2019Article
- Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.Genome biology and evolution · 2018Article
- The fitness costs and trade-off shapes associated with the exclusion of nine antibiotics by OmpF porin channels.The ISME journal · 2017Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial species are internally diverse in genomic and multi-locus gene comparisons. The ecological causes of phenotypic and genotypic diversity within species are far less well understood. Here, we focus on the competitive fitness for growth on nutrients within Escherichia coli, an internally rich species. Competition experiments in nutrient-limited chemostats revealed that members of the ECOR collection exhibited a wide continuum of competitive abilities, with some fitter and some less fit than the lab strain MG1655. We observed an inverse relationship between competitiveness and the resistance of strains to detergent and antibiotic, consistent with the notion that membrane permeability and competitive fitness are linked by a trade-off between self-preservation and nutritional competence (SPANC); high permeability has a postulated cost in antibacterial sensitivity whereas a low permeability has a cost in nutrient affinity. Isolates moved along the markedly nonlinear trade-off curve by mutational adaptation; an ECOR strain sensitive to antibacterials and a good competitor was easily converted by mutation into a mutant with higher resistance but poorer competition in the presence of low antibiotic concentrations. Conversely, a resistant ECOR strain changed into a better competitor after a short period of selection under nutrient limitation. In both directions, mutations can affect porin proteins and outer membrane permeability, as indicated by protein analysis, gene sequencing and an independent assay of outer membrane permeability. The extensive, species-wide diversity of E. coli in ecologically important traits can thus be explained as an evolutionary consequence of a SPANC trade-off driven by antagonistic pleiotropy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.