ArticleJournal of the Royal Society, Interface2013
Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- Exploring nonlinear phenomena in animal vocalizations through oscillator theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The seasons within: a theoretical perspective on photoperiodic entrainment and encoding.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Limits of entrainment of circadian neuronal networks.Chaos (Woodbury, N.Y.) · 2023Article
- Article
- Induction of internal circadian desynchrony by misaligning zeitgebers.Scientific reports · 2022Article
- Principles underlying the complex dynamics of temperature entrainment by a circadian clock.iScience · 2021Article
- A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light.Scientific reports · 2021Article
- Article
- Diversified regulation of circadian clock gene expression following whole genome duplication.PLoS genetics · 2020Article
- Nonlinear phenomena in models of the circadian clock.Journal of the Royal Society, Interface · 2020Article
- Clocks in the Wild: Entrainment to Natural Light.Frontiers in physiology · 2020Article
- Conceptual Models of Entrainment, Jet Lag, and Seasonality.Frontiers in physiology · 2020Article
- Differentiating external zeitgeber impact on peripheral circadian clock resetting.Scientific reports · 2019Article
- Photoperiodic Requirements for Induction and Maintenance of Rhythm Bifurcation and Extraordinary Entrainment in Male Mice.Clocks & sleep · 2019Article
- Allostatic adaptation and personalized physiological trade-offs in the circadian regulation of the HPA axis: A mathematical modeling approach.Scientific reports · 2019Article
- Are 24-hour motor activity patterns associated with continued rapid response to ketamine?Neuropsychiatric disease and treatment · 2018Article
- Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine's Rapid Antidepressant Properties.Biological psychiatry · 2017Article
- The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing: a modeling approach.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks are internal timekeepers present in almost all organisms. Driven by a genetic network of highly conserved structure, they generate self-sustained oscillations that entrain to periodic external signals such as the 24 h light-dark cycle. Vertebrates possess multiple, functionally overlapping homologues of the core clock genes. Furthermore, vertebrate clocks entrain to a range of periods three times as narrow as that of other organisms. We asked whether genetic redundancies play a role in governing entrainment properties and analysed locomotor activity rhythms of genetically modified mice lacking one set of clock homologues. Exposing them to non-24 h light-dark cycles, we found that the mutant mice have a wider entrainment range than the wild types. Spectral analysis furthermore revealed nonlinear phenomena of periodically forced self-sustained oscillators for which the entrainment range relates inversely to oscillator amplitude. Using the forced oscillator model to explain the observed differences in entrainment range between mutant and wild-type mice, we sought to quantify the overall oscillator amplitude of their clocks from the activity rhythms and found that mutant mice have weaker circadian clocks than wild types. Our results suggest that genetic redundancy strengthens the circadian clock leading to a narrow entrainment range in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.