Evidence map›Paper›PMID 23676423›Full record

SynthesisThe American journal of clinical nutrition2013

Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis.

Jang Yel Shin, Pengcheng Xun, Yasuyuki Nakamura, Ka He

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03404700 (Determining Dietary Pattern Accompanying Egg Intake Using Remote Food Photography Method), which is not on this map. Cited by 118 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03404700 nacompletednot on this mapstarted 2018, after this paper: background citation

Determining Dietary Pattern Accompanying Egg Intake Using Remote Food Photography Method

TypeinterventionalSponsorTexas Tech UniversityRan2018 to 2018Enrolled48ConditionsDiabetes Mellitus, Type 2, Insulin ResistanceArmsEgg breakfast, Egg breakfast with high saturated fat, Cereal breakfast, Cereal breakfast with high saturated fat
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jang Yel ShinDepartment of Nutrition, Gillings Schools of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pengcheng Xun
Yasuyuki Nakamura
Ka He

Funding

Amino Acids, Protein, and BMI in Adults Across CulturesR21DK073812 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAHE, KA · 2007 to 2008
$413k
Serum fatty acids and ischemic stroke in womenR21NS056445 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAHE, KA · 2008 to 2009
$393k
NIDDK NIH HHS R21DK073812NINDS NIH HHS R21NS056445
6 · The paper itself

Abstract

backgroundThe associations of egg consumption with cardiovascular disease (CVD) and diabetes are still unclear.

objectiveWe aimed to quantitatively summarize the literature on egg consumption and risk of CVD, cardiac mortality, and type 2 diabetes by conducting a meta-analysis of prospective cohort studies.

designA systematic literature review was conducted for published studies in PubMed and EMBASE through March 2012. Additional information was retrieved through Google or a hand review of the reference from relevant articles. Studies were included if they had a prospective study design, were published in English-language journals, and provided HRs and 95% CIs for the associations of interest. Data were independently extracted by 2 investigators, and the weighted HRs and 95% CIs for the associations of interest were estimated by using a random-effects model.

resultsA total of 22 independent cohorts from 16 studies were identified, including participants ranging in number from 1600 to 90,735 and in follow-up time from 5.8 to 20.0 y. Comparison of the highest category (≥1 egg/d) of egg consumption with the lowest (<1 egg/wk or never) resulted in a pooled HR (95% CI) of 0.96 (0.88, 1.05) for overall CVD, 0.97 (0.86, 1.09) for ischemic heart disease, 0.93 (0.81, 1.07) for stroke, 0.98 (0.77, 1.24) for ischemic heart disease mortality, 0.92 (0.56, 1.50) for stroke mortality, and 1.42 (1.09, 1.86) for type 2 diabetes. Of the studies conducted in diabetic patients, the pooled HR (95% CI) was 1.69 (1.09, 2.62) for overall CVD.

conclusionsThis meta-analysis suggests that egg consumption is not associated with the risk of CVD and cardiac mortality in the general population. However, egg consumption may be associated with an increased incidence of type 2 diabetes among the general population and CVD comorbidity among diabetic patients.

Indexed as

Cardiovascular DiseasesDatabases, FactualDiabetes Mellitus, Type 2EggsHumansIncidenceRandomized Controlled Trials as TopicRisk Factors

Identifiers

PMID23676423
PMCPMC3683816

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.