ArticleBMC medical genetics2013
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition.
Article in BMC medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis.Journal of inflammation research · 2024Article
- IL2RB Is a Prognostic Biomarker Associated with Immune Infiltrates in Pan-Cancer.Journal of oncology · 2022Article
- Genetic analysis of the relation between IL2RA/IL2RB and rheumatoid arthritis risk.Molecular genetics & genomic medicine · 2019Article
- Determination of Genes Related to Uveitis by Utilization of the Random Walk with Restart Algorithm on a Protein-Protein Interaction Network.International journal of molecular sciences · 2017Article
- Lack of association of C3 gene with uveitis: additional insights into the genetic profile of uveitis regarding complement pathway genes.Scientific reports · 2017Article
- Article
- Interleukin-21 polymorphism affects gene expression and is associated with risk of ischemic stroke.Inflammation · 2014Article
- Predisposition to Behçet's disease and VKH syndrome by genetic variants of miR-182.Journal of molecular medicine (Berlin, Germany) · 2014Article
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18 authors at 13 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, different genetic variants located within the IL2/IL21 genetic region as well as within both IL2RA and IL2RB loci have been associated to multiple autoimmune disorders. We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition.
methodsA total of 196 patients with endogenous non-anterior uveitis and 760 healthy controls, all of them from Caucasian population, were included in the current study. The IL2/IL21 (rs2069762, rs6822844 and rs907715), IL2RA (2104286, rs11594656 and rs12722495) and IL2RB (rs743777) genetic variants were genotyped using TaqMan® allelic discrimination assays.
resultsA statistically significant difference was found for the rs6822844 (IL2/IL21 region) minor allele frequency in the group of uveitis patients compared with controls (P(-value)=0.02, OR=0.64 CI 95%=0.43-0.94) although the significance was lost after multiple testing correction. Furthermore, no evidence of association with uveitis was detected for the analyzed genetic variants of the IL2RA or IL2RB loci.
conclusionOur results indicate that analyzed IL2/IL21, IL2RA and IL2RB polymorphisms do not seem to play a significant role on the non-anterior uveitis genetic predisposition although further studies are needed in order to clear up the influence of these loci on the non-anterior uveitis susceptibility.
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