ArticleRespiratory research2013
Systemic inflammation, depression and obstructive pulmonary function: a population-based study.
Article in Respiratory research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Efficacy and safety of oral proprietary Chinese medicines in the treatment of stable chronic obstructive pulmonary disease: a network meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Antioxidant and associated capacities of Camu camu (Myrciaria dubia): a systematic review.Journal of alternative and complementary medicine (New York, N.Y.) · 2015Pooled it
- Association between comorbidity and chronic obstructive pulmonary disease: a systematic review and meta-analysis of Mendelian randomization studies.Therapeutic advances in respiratory diseasePooled it
- Lung function trajectory: a partial mediator of the relationships between depressive symptoms and health-related quality of life in the aging population.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Comparative Performance of 3 Analytical Models in Identifying Associated Factors of Pulmonary Dysfunction-Depression Comorbidity: China Health and Retirement Longitudinal Study-Based Nationwide Cross-Sectional Study.JMIR medical informatics · 2026Article
- Depressive Symptoms, Anxiety, Insomnia, and Sexual Quality of Life in Patients with Chronic Obstructive Pulmonary Disease from the Podlaskie Voivodeship, Poland: A Cross-Sectional Pilot Study.Journal of clinical medicine · 2026Article
- Effect of Incentive Spirometry Exercise on Perceived Stress in Chronic Obstructive Pulmonary Disease Patients: A Quasi-Experimental Study.Health science reports · 2026Article
- Lung function as a mediator: bridging appendicular skeletal muscle mass and dementia in middle-aged and older Chinese adults.European journal of medical research · 2026Article
- Association between the C-reactive protein-albumin-lymphocyte index and incident depression in patients with chronic obstructive pulmonary disease: a prospective cohort study from the UK biobank.Frontiers in medicine · 2026Article
- Association between life's crucial 9 and lung health: a population-based study.BMC pulmonary medicine · 2025Article
- Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Association Between Chronic Neck Pain and Increased Risk of Chronic Respiratory Diseases in Middle-Aged and Elderly Chinese Adults: A Cohort Study Based on CHARLS.Journal of pain research · 2025Article
- Moderating role of live microbe between chronic inflammatory airway disease and depressive symptoms.Frontiers in nutrition · 2025Article
- Inter-relationships of depression and anxiety symptoms among widowed and non-widowed older adults: findings from the Chinese Longitudinal Healthy Longevity Survey based on network analysis and propensity score matching.Frontiers in public health · 2025Article
- Psychiatric Disorders in Patients with Chronic Obstructive Pulmonary Disease: Clinical Significance and Treatment Strategies.Journal of clinical medicine · 2024Review
- Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.BMC medicine · 2024Article
- Enhanced polygenic risk score incorporating gene-environment interaction suggests the association of major depressive disorder with cardiac and lung function.Briefings in bioinformatics · 2024Article
- Associations between different body mass index and lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study.BMC pulmonary medicine · 2024Article
- NMDAR Down-Regulation: Dual - Hit Molecular Target For COPD - Depression Comorbidity.Journal of inflammation research · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLevels of Interleukin-6 (IL-6) and C-creative protein (CRP) indicating systemic inflammation are known to be elevated in chronic diseases including chronic obstructive pulmonary disease (COPD) and depression. Comorbid depression is common in patients with COPD, but no studies have investigated whether proinflammatory cytokines mediate the association between pulmonary function and depressive symptoms in healthy individuals with no known history of obstructive pulmonary diseases.
methodsIn a population-based sample (n = 2077) of individuals aged 55 and above with no known history of obstructive pulmonary disease in the Singapore Longitudinal Ageing Study (SLAS), we analyzed the relationships between IL-6 and CRP, depressive symptoms (GDS-15 ≥5) and obstructive pulmonary function (FEV1% predicted and FEV1/FVC% predicted).
resultsHigh serum levels of IL-6 and CRP were associated with greater prevalence of depressive symptoms (p < 0.05). High IL-6, high CRP and depressive symptoms were independently associated with decreased FEV1% predicted and FEV1/FVC% predicted after adjusting for smoking status, BMI and number of chronic inflammatory diseases. Increasing grades of combination of inflammatory markers and/or depressive symptoms was associated with progressive increases in pulmonary obstruction. In hierarchical models, the significant association of depressive symptoms with pulmonary obstruction was reduced by the presence of IL-6 and CRP.
conclusionsThis study found for the first time an association of depressive symptoms and pulmonary function in older adults which appeared to be partly mediated by proinflammatory cytokines. Further studies should be conducted to investigate proinflammatory immune markers and depressive symptoms as potential phenotypic indicators for chronic obstructive airway disorders in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.