Evidence map›Paper›PMID 23675750›Full record

ArticleAIDS patient care and STDs2013

Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants.

Oluwatoyin M Adeyemi, Britt Livak, Jennifer Orsi, Marshall J Glesby, Maria C Villacres, Kathleen M Weber, Anjali Sharma, Elizabeth Golub, Mary Young, Mardge Cohen and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS patient care and STDs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Oluwatoyin M AdeyemiCORE Center and John H. Stroger Hospital, Chicago, IL 60612, USA. Oluwatoyin_adeyemi@rush.edu
Britt Livak
Jennifer Orsi
Marshall J Glesby
Maria C Villacres
Kathleen M Weber
Anjali Sharma
Elizabeth Golub
Mary Young
Mardge Cohen
Phyllis C Tien
John Peter Smith Hospital · USRush University Medical Center · USCornell University · USGeorgetown University · USJohns Hopkins University · USSUNY Downstate Health Sciences University · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Complications of Chronic Viral InfectionsK24AI078884 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLESBY, MARSHALL J · 2008 to 2012
$892k
HIV and Adiposity in Women: Effects on Bone MetabolismK23AR061993 · NIAMS · SUNY DOWNSTATE MEDICAL CENTER · PI SHARMA, ANJALI · 2012 to 2016
$773k
NCRR NIH HHS UL1 RR024131NIAID NIH HHS K24AI078884NIAID NIH HHS P30-AI082157NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01-AI-31834NIAID NIH HHS U01-AI-34989NIAID NIH HHS U01-AI-34993NIAID NIH HHS U01-AI-34994NIAID NIH HHS U01-AI-35004NIAID NIH HHS U01-AI-42590NIAMS NIH HHS K23 AR061993NICHD NIH HHS U01-HD-32632PHS HHS U01-A1-3183417S1
6 · The paper itself

Abstract

We explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women's Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US. Vitamin D levels 20-29 ng/mL were considered insufficient and <20 ng/mL deficient. IR was estimated using the homeostasis model assessment (HOMA) and a clinically significant cut-off ≥2.6 was used for HOMA-IR. In the unadjusted analysis, women who were vitamin D insufficient or deficient were 1.62 (95% CI: 1.01-2.61, p=0.05) and 1.70 (95% CI: 1.11-2.60, p=0.02) times more likely to have HOMA values≥2.6 compared to women with sufficient vitamin D. The association did not remain significant after adjustment for factors associated with IR. Among the 754 HIV-infected women, current PI use (OR 1.61, 95% CI: 1.13-2.28, p=0.008) remained independently associated with HOMA ≥2.6 while vitamin D insufficiency (OR 1.80, 95% CI: 0.99-3.27, p=0.05) was marginally associated with HOMA ≥2.6 after adjustment. Ethnicity, body mass index, smoking status, and hepatitis C status were independently associated with insulin resistance in HIV-infected and uninfected women. We found a marginally significant association between vitamin D insufficiency and insulin resistance among nondiabetic HIV-infected WIHS women.

Indexed as

Insulin ResistanceAdultAgedBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2FemaleGas Chromatography-Mass SpectrometryHIV InfectionsHumansInsulinMiddle AgedProspective StudiesRegression AnalysisRisk FactorsSocioeconomic FactorsBlood GlucoseInsulinVitamin D

Identifiers

PMID23675750
PMCPMC3671624
OpenAlexW2002552043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.