ArticlePloS one2013
Reversed scototaxis during withdrawal after daily-moderate, but not weekly-binge, administration of ethanol in zebrafish.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish (Frontiers in systems neuroscience · 2026Article
- Repeated microdoses of LSD do not alter anxiety or boldness in zebrafish.Scientific reports · 2024Article
- β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.Scientific reports · 2024Article
- Anticonvulsant Role of Adenosine is Blunted During Alcohol Withdrawal Syndrome in an Adult Zebrafish Model.Neurochemical research · 2023Article
- Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish.Scientific reports · 2023Article
- Teleosts as behaviour test models for social stress.Frontiers in behavioral neuroscience · 2023Review
- Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents.Current neuropharmacology · 2022Review
- Zebrafish aversion to infrasound in an open field test.Frontiers in behavioral neuroscience · 2022Article
- Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Robust behavioural effects in response to acute, but not repeated, terpene administration in Zebrafish (Danio rerio).Scientific reports · 2021Article
- Analysis of the potential behavioral impact of methanol when used as a solvent: Dataset from zebrafish (Data in brief · 2021Article
- Article
- Opposing effects of acute and repeated nicotine exposure on boldness in zebrafish.Scientific reports · 2020Article
- Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal.PeerJ · 2019Article
- Establishing zebrafish as a model to study the anxiolytic effects of scopolamine.Scientific reports · 2017Article
- CORoyal Society open science · 2017Article
- Article
- Article
- A history-based method to estimate animal preference.Scientific reports · 2016Article
- Acute fluoxetine exposure alters crab anxiety-like behaviour, but not aggressiveness.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol abuse can lead to severe psychological and physiological damage. Little is known, however, about the relative impact of a small, daily dose of alcohol (daily-moderate schedule) versus a large, once per week dose (weekly-binge schedule). In this study, we examined the effect of each of these schedules on behavioural measures of anxiety in zebrafish (Danio rerio). Adult wild-type zebrafish were administered either 0.2% ethanol on a daily-moderate schedule or 1.4% ethanol on a weekly-binge schedule for a period of 21 days, and then tested for scototaxis (preference for darkness) during withdrawal. Compared to a control group with no alcohol exposure, the daily-moderate group spent significantly more time on the light side of the arena (indicative of decreased anxiety) on day two of withdrawal, but not day 9 of withdrawal. The weekly-binge group was not significantly different from the control group on either day of withdrawal and showed no preference for either the light or dark zones. Our results indicate that even a small dose of alcohol on a daily basis can cause significant, though reversible, changes in behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.