SynthesisPloS one2013
Color Doppler imaging analysis of retrobulbar blood flow velocities in primary open-angle glaucomatous eyes: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Laser doppler holography for choroidal blood flow assessment: a systematic review of technical capabilities, validation studies, and clinical applications.Frontiers in ophthalmology · 2026Pooled it
- Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies.BMC ophthalmology · 2016Pooled it
- Alterations in retrobulbar haemodynamics in thyroid eye disease.Eye (London, England) · 2023Trial
- Ocular Color Doppler Ultrasound (OCDUS) in Diagnosis and Monitoring of Ophthalmological, Cerebrovascular and Systemic Diseases: A Narrative Review.Journal of clinical medicine · 2026Review
- Color Doppler Imaging Assessment of Ocular Blood Flow Following Ab Externo Canaloplasty in Primary Open-Angle Glaucoma.Journal of clinical medicine · 2024Article
- Cardiac Surgery Patients Have Reduced Vascularity and Structural Defects of the Retina Similar to Persons with Open-Angle Glaucoma.Diagnostics (Basel, Switzerland) · 2024Article
- Glaucoma Surgery and Ocular Blood Flow in Colour Doppler Imaging: Is There a Link?Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- Measurement of Retrobulbar Blood Flow and Vascular Reactivity-Relevance for Ocular and Cardiovascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Incidence Rates and Risk Ratios of Normal Tension Glaucoma in Patients with Chronic Rhinosinusitis: A Population-Based Longitudinal Follow-Up Study.Life (Basel, Switzerland) · 2023Article
- The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Ocular blood flow and choroidal thickness in ocular hypertension.International ophthalmology · 2022Article
- Feasibility of MRI to assess differences in ophthalmic artery blood flow rate in normal tension glaucoma and healthy controls.Acta ophthalmologica · 2021Article
- Article
- Ocular and Systemic Risk Factors and Correlation with Glaucomatous Damage in Normal Tension Glaucoma.Cureus · 2018Article
- Gonadal Hormones and Retinal Disorders: A Review.Frontiers in endocrinology · 2018Review
- The clinical effectiveness of tafluprost on Japanese normal-tension glaucoma patients.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Does steep Trendelenburg positioning effect the ocular hemodynamics and intraocular pressure in patients undergoing robotic cystectomy and robotic prostatectomy?International urology and nephrology · 2017Article
- Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters.PloS one · 2017Article
- Article
- Macular microvasculature alterations in patients with primary open-angle glaucoma: A cross-sectional study.Medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo analyze the diagnostic value of color Doppler imaging (CDI) of blood flow in the retrobulbar vessels of eyes with primary open-angle glaucoma (POAG).
methodsPertinent publications were retrieved from the Cochrane Central Register of Controlled Trials, PubMed and the ISI Web of Knowledge up to October 2012. Changes in peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) of the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary artery (SPCA) of POAG eyes and normal controls were evaluated by CDI. Subgroup analyses were conducted according to whether patients received IOP-lowering drugs treatment and were defined as treated and untreated.
resultsPSV and EDV were statistically significantly reduced in the OA of POAG eyes (P = 0.0002; P<0.00001; respectively), with significant heterogeneity (P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 85%; respectively). Similar results were demonstrated for the CRA (P<0.00001; respectively) and SPCA (P = 0.005; P<0.00001; respectively), with significant heterogeneities for both the CRA (P(heterogeneity)<0.00001, I² = 81%; P(heterogeneity)<0.00001, I² = 98%; respectively) and the SPCA (P(heterogeneity)<0.00001, I² = 96%; P(heterogeneity)<0.00001, I² = 93%; respectively). Significant increases in RI were found in all retrobulbar vessels (P<0.00001; respectively), with significant heterogeneities (P(heterogeneity)<0.00001, I² = 95%; P(heterogeneity)<0.00001, I² = 94%; P(heterogeneity)<0.00001, I² = 97%; respectively).
conclusionsThis meta-analysis suggests that CDI is a potential diagnostic tool for POAG.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.