Evidence map›Paper›PMID 23675387›Full record

ArticleSoft matter2013

Influence of droplet size, pH and ionic strength on endotoxin-triggered ordering transitions in liquid crystalline droplets.

Daniel S Miller, Nicholas L Abbott

Abstract read
In one paragraph

Article in Soft matter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Interplay of structure, elasticity, and dynamics in actin-based nematic materials.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  10. Design of Responsive and Active (Soft) Materials Using Liquid Crystals.Annual review of chemical and biomolecular engineering · 2016
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Blue-phase liquid crystal droplets.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  16. Article
  17. Design of Functional Materials based on Liquid Crystalline Droplets.Chemistry of materials : a publication of the American Chemical Society · 2014
    Article
  18. Article
  19. Article
  20. Introduction to optical methods for characterizing liquid crystals at interfaces.Langmuir : the ACS journal of surfaces and colloids · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel S MillerDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, Wisconsin 53706-1607, USA. abbott@engr.wisc.edu.
Nicholas L Abbott

Funding

BIOMOLECULAR ANALYSIS USING LIQUID CRYSTALSR01CA108467 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ABBOTT, NICHOLAS L · 2004 to 2013
$3.8M
Nano-Structure Surfaces and Liquid Crystal AnalysisR21CA105730 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI SCHILLER, JOAN H · 2004 to 2005
$259k
NCI NIH HHS R01 CA108467NCI NIH HHS R21 CA105730
6 · The paper itself

Abstract

We report an investigation of ordering transitions that are induced in water-dispersed, micrometer-sized droplets of a thermotropic liquid crystal (LC) by the bacterial lipopolysaccharide endotoxin. We reveal that the ordering transitions induced by endotoxin - from a bipolar state of the droplets to a radial state - are strongly dependent on the size of the LC droplets. Specifically, as the diameters of the LC droplets increase from 2 μm to above 10 μm (in phosphate buffered saline with an ionic strength of 90 mM and a pH of 7.2), we measured the percentage of droplets exhibiting a radial configuration in the presence of 100 pg/mL endotoxin to decrease from 98 ± 1 % to 3 ± 2 %. In addition, we measured a decrease in either the ionic strength or pH of the aqueous phase to reduce the percentage of droplets exhibiting a radial configuration in the presence of endotoxin. These results, when interpreted within the context of a simple thermodynamic model that incorporates the contributions of elasticity and surface anchoring to the free energies of the LC droplets, lead us to conclude that (i) the elastic constant K

Identifiers

PMID23675387
PMCPMC3651735

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.