ArticleFrontiers in psychiatry2013
Issues in the management of acute agitation: how much current guidelines consider safety?
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- "Pharmacological management of acute agitation in psychiatric patients: an umbrella review".BMC psychiatry · 2025Pooled it
- Rapid Tranquilization for Psychiatric Patients with Psychomotor Agitation: What is Known About it?The Psychiatric quarterly · 2017Pooled it
- The Turkish Version of the Modified Agitation Severity Scale: Validity and Reliability Study.International journal of methods in psychiatric research · 2026Article
- A Comprehensive Understanding of Psychomotor Agitation: From Causes to Hospital Care.Current neuropharmacology · 2025Review
- NANDA nursing diagnoses associated with the occurrence of psychomotor agitation in patients with severe mental disorder: a cross-sectional study.BMC nursing · 2023Article
- Clinical and Sociodemographic Profile of Psychomotor Agitation in Mental Health Hospitalisation: A Multicentre Study.International journal of environmental research and public health · 2022Article
- Acute psychomotor agitation - challenges for psychiatrists and neurologists: a case study.Postepy psychiatrii neurologii · 2022Article
- Efficacy and safety of intranasal haloperidol in an acute Psychiatry Unit: a pilot study on schizophrenic patients with mild-modedate agitation.Actas espanolas de psiquiatria · 2021Article
- The Management of Psychomotor Agitation Associated with Schizophrenia or Bipolar Disorder: A Brief Review.International journal of environmental research and public health · 2021Review
- Evaluation of the use of chlorpromazine for agitation in pediatric patients.The mental health clinician · 2021Article
- Which Emergent Medication Should I Give Next? Repeated Use of Emergent Medications to Treat Acute Agitation.Frontiers in psychiatry · 2021Review
- Psychometric Characteristics and Sociodemographic Adaptation of the Corrigan Agitated Behavior Scale in Patients With Severe Mental Disorders.Frontiers in psychology · 2021Article
- Improving the management of acutely agitated patients in the emergency department through implementation of Project BETA (Best Practices in the Evaluation and Treatment of Agitation).Journal of the American College of Emergency Physicians open · 2020Review
- First line in psychiatric emergency: pre-hospital emergency protocol for mental disorders in Iran.BMC emergency medicine · 2020Article
- A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population.Neuropsychiatric disease and treatment · 2019Review
- Management of Violence and Aggression in Emergency Environment; a Narrative Review of 200 Related Articles.Advanced journal of emergency medicine · 2019Review
- [Diagnosis, differential diagnosis and therapy of substance use disorders in general hospital (general section)].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2018Review
- 1st International Experts' Meeting on Agitation: Conclusions Regarding the Current and Ideal Management Paradigm of Agitation.Frontiers in psychiatry · 2018Review
- Protocol for the management of psychiatric patients with psychomotor agitation.BMC psychiatry · 2017Article
- State of Acute Agitation at Psychiatric Emergencies in Europe: The STAGE Study.Clinical practice and epidemiology in mental health : CP & EMH · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agitated behavior constitutes up to 10% of emergency psychiatric interventions. Pharmacological tranquilization is often used as a valid treatment for agitation but a strong evidence base does not underpin it. Available literature shows different recommendations, supported by research data, theoretical considerations, or clinical experience. Rapid tranquilization (RT) is mainly based on parenteral drug treatment and the few existing guidelines on this topic, when suggesting the use of first generation antipsychotics and benzodiazepines, include drugs with questionable tolerability profile such as chlorpromazine, haloperidol, midazolam, and lorazepam. In order to systematically evaluate safety concerns related to the adoption of such guidelines, we reviewed them independently from principal diagnosis while examining tolerability data for suggested treatments. There is a growing evidence about safety profile of second generation antipsychotics for RT but further controlled studies providing definitive data in this area are urgently needed.
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